一种针对70千道尔顿细胞表面蛋白的荚膜组织胞浆菌特异性IgG1同种型单克隆抗体H1C，在小鼠组织胞浆菌病中没有保护作用。
A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis.
作者信息
Lopes Livia Cristina Liporagi, Guimarães Allan J, de Cerqueira Mariana Duarte, Gómez Beatriz L, Nosanchuk Joshua D
机构信息
Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
出版信息
Clin Vaccine Immunol. 2010 Jul;17(7):1155-8. doi: 10.1128/CVI.00033-10. Epub 2010 May 19.
Abstract
Monoclonal antibodies to Histoplasma capsulatum can modify pathogenesis. We now show that monoclonal antibody H1C to a 70-kDa antigen increases intracellular fungal growth and reduces macrophage nitric oxide release but has no effect on fungal burden or survival in murine infection. This further demonstrates the complexities of host-pathogen interactions.
摘要
针对荚膜组织胞浆菌的单克隆抗体可改变发病机制。我们现在发现，针对一种70 kDa抗原的单克隆抗体H1C可增加细胞内真菌生长并减少巨噬细胞一氧化氮释放，但对小鼠感染中的真菌负荷或存活率没有影响。这进一步证明了宿主-病原体相互作用的复杂性。
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