Pace Gianna, Di Massimo Caterina, De Amicis Daniela, Corbacelli Carlo, Di Renzo Laura, Vicentini Carlo, Miano Lucio, Tozzi Ciancarelli Maria Giuliana
Department of Health Sciences, University of L'Aquila, L'Aquila, Italy. giannapace @ gmail.com
Urol Int. 2010;85(3):328-33. doi: 10.1159/000315064. Epub 2010 May 20.
The aim was to verify whether oxidative stress could represent a common key factor of benign prostatic hyperplasia (BPH) and prostate cancer (PCa).
15 patients affected by BPH, 15 with PCa and 15 controls were enrolled. Blood samples were withdrawn systemically and locally during radical retropubic prostatectomy in patients with PCa and during transvesical retropubic adenomectomy in patients diagnosed with BPH. Plasma oxidized low-density lipoprotein, peroxides, and total equivalent antioxidant capacity (TEAC) including plasma superoxide dismutase (SOD) determination were analyzed as oxidative markers.
With respect to the control group, high plasma peroxides and decreased TEAC levels were measured in patients affected by both PCa and BPH. Plasma peroxides were significantly higher in patients with PCa with respect to BPH. A positive correlation was found between peroxides and TEAC values in samples withdrawn locally in patients affected by PCa. An inverse correlation between peroxides and TEAC was observed in patients with BPH. No statistically significant modifications were observed as concerns SOD activity and LDL oxidability.
Our findings confirm a significant unbalance of redox status in patients affected by BPH and PCa, and suggest a potential involvement of oxidative stress as a determinant in the pathogenesis of these diseases.
旨在验证氧化应激是否可能是良性前列腺增生（BPH）和前列腺癌（PCa）的共同关键因素。
招募了15例BPH患者、15例PCa患者和15名对照者。对PCa患者在耻骨后根治性前列腺切除术期间以及BPH患者在经膀胱耻骨后腺瘤切除术中进行全身和局部采血。分析血浆氧化型低密度脂蛋白、过氧化物以及包括血浆超氧化物歧化酶（SOD）测定在内的总等效抗氧化能力（TEAC）作为氧化标志物。
与对照组相比，PCa和BPH患者的血浆过氧化物水平升高，TEAC水平降低。PCa患者的血浆过氧化物水平显著高于BPH患者。在PCa患者局部采集的样本中，过氧化物与TEAC值之间呈正相关。在BPH患者中，过氧化物与TEAC呈负相关。未观察到SOD活性和低密度脂蛋白氧化能力有统计学意义的改变。
我们的研究结果证实了BPH和PCa患者氧化还原状态存在显著失衡，并提示氧化应激可能作为这些疾病发病机制的一个决定因素参与其中。
