来自凤尾草的细胞毒性二萜类化合物和倍半萜类化合物。

Cytotoxic diterpenoids and sesquiterpenoids from Pteris multifida.

作者信息

Ge Xin, Ye Guan, Li Ping, Tang Wen-Jie, Gao Jin-Li, Zhao Wei-Min

机构信息

Central Research Institute of Shanghai Pharmaceutical Group, Shanghai 201203, People's Republic of China.

出版信息

J Nat Prod. 2008 Feb;71(2):227-31. doi: 10.1021/np0706421. Epub 2008 Jan 9.

DOI:10.1021/np0706421

PMID:18181575

Abstract

Three new ent-kaurane diterpenoids, named pterokaurane M 1-M 3 ( 1- 3) and three new C 14 pterosin-sesquiterpenoids, named multifidoside A-C ( 4- 6), along with 18 known compounds, were isolated from the whole plants of Pteris multifida . The structures of 1- 6 were established using spectroscopic methods, including extensive 2D NMR and CD analyses. Compounds 4 and 5 showed cytotoxicity against the HepG2 tumor cell line with IC 50 values of less than 10 microM.

摘要

从凤尾草全草中分离得到3个新的对映-贝壳杉烷二萜类化合物，命名为蕨贝壳杉烷M 1-M 3（1-3），以及3个新的C14蕨素倍半萜类化合物，命名为多裂苷A-C（4-6），同时还得到18个已知化合物。通过光谱方法，包括广泛的二维核磁共振和圆二色光谱分析确定了1-6的结构。化合物4和5对HepG2肿瘤细胞系显示出细胞毒性，半数抑制浓度（IC50）值小于10微摩尔。