Ayena K D, Amedome K M, Agbo A R D, Kpetessou-Ayivon A L, Dzidzinyo B K, Djagnikpo P A, Banla M, Balo K P
Service d'ophtalmologie CHU Tokoin, Lomé, Togo.
Med Trop (Mars). 2010 Apr;70(2):137-40.
The twofold purpose of this study in people living with human immunodeficiency virus (PLHIV/AIDS) and undergoing highly active antiretroviral treatment (HAART) was to determine the prevalence of ocular manifestations and its correlation with CD4 T-cell count.
All patients who attended 2 NGO care centers that manage PLHIV/AIDS in Lomé, Togo between August and October 2005 were recruited. CD4 T-cell counts and use of antiretroviral treatment was noted. A thorough eye examination was performed in all cases.
A total of 422 PLHIV/SIDA were recruited including 281 who were undergoing HAART. The sex-ratio was 2 female/1 male. Mean age was 34 +/- 2294 years. Involvement of the anterior segment was observed in 36.3% of patients and involvement of the posterior segment in 54.1%. The second most common ocular manifestation was ophthalmic herpes zoster of the anterior segment (19.6%) secondary to conjunctivitis (57.8%). One case of palpebral and conjunctival Kaposi's sarcoma was noted. The most common type of posterior segment involvement was cotton-wool nodules (35.5%). Five cases of CMV retinitis were observed.
A longitudinal study in PLHIV/AIDS will be needed to better evaluate the correlation between ocular manifestations and CD4 T-cell count.
本研究针对接受高效抗逆转录病毒治疗（HAART）的人类免疫缺陷病毒感染者（PLHIV/AIDS）有两个目的，即确定眼部表现的患病率及其与CD4 T细胞计数的相关性。
招募了2005年8月至10月期间在多哥洛美2个管理PLHIV/AIDS的非政府组织护理中心就诊的所有患者。记录CD4 T细胞计数和抗逆转录病毒治疗的使用情况。所有病例均进行了全面的眼部检查。
共招募了422例PLHIV/SIDA患者，其中281例正在接受HAART治疗。男女比例为2∶1。平均年龄为34±2.294岁。36.3%的患者出现前段受累，54.1%的患者出现后段受累。第二常见的眼部表现是前段眼部带状疱疹（19.6%），继发于结膜炎（57.8%）。记录到1例睑结膜卡波西肉瘤。后段受累最常见的类型是棉绒斑（35.5%）。观察到5例巨细胞病毒性视网膜炎。
需要对PLHIV/AIDS患者进行纵向研究，以更好地评估眼部表现与CD4 T细胞计数之间的相关性。
