Mobley K A, Wandless J G, Fell D
Department of Anaesthesia, Leicester Royal Infirmary.
Anaesthesia. 1991 Jun;46(6):500-1. doi: 10.1111/j.1365-2044.1991.tb11697.x.
Serum bupivacaine concentrations were measured in 12 children who underwent elective herniotomy and who received analgesia in the form of wound infiltration. Mean (SD) peak concentration was 0.36 (0.14) micrograms/ml and time to peak concentration was 14.6 (7.2) minutes after infiltration of 1.25 mg/kg of bupivacaine. These concentrations are lower than those associated with other local anaesthetic blocks and well below potentially toxic levels. Wound infiltration provides a simple, effective and safe method of providing postoperative analgesia for hernia repair in children.
对12名接受择期疝修补术并采用伤口浸润镇痛的儿童测量了血清布比卡因浓度。在浸润1.25mg/kg布比卡因后，平均（标准差）峰值浓度为0.36（0.14）微克/毫升，达到峰值浓度的时间为14.6（7.2）分钟。这些浓度低于与其他局部麻醉阻滞相关的浓度，且远低于潜在中毒水平。伤口浸润为儿童疝修补术提供了一种简单、有效且安全的术后镇痛方法。
