Kastrissios H, Triggs E J, Sinclair F, Moran P, Smithers M
Department of Pharmacy, University of Queensland, Australia.
Eur J Clin Pharmacol. 1993;44(6):555-7. doi: 10.1007/BF02440858.
After routine inguinal herniorrhaphy we gave 12 patients a wound infiltration regimen of bolus doses of 20 ml of 0.5% bupivacaine via a catheter within the wound and rectally administered indomethacin (100 mg). Peak venous plasma bupivacaine concentrations ranged from 0.07 mg.l-1 to 1.14 mg.l-1 (mean (SD) 0.47 (0.33) mg.l-1), and occurred at between 0.25 and 2 h after the first dose. Plasma concentrations were well below the toxic threshold of 4 mg.l-1 and there was no accumulation. The regimen provided satisfactory analgesia. There were no wound infections nor signs of toxicity.
在进行常规腹股沟疝修补术后，我们对12例患者采用了一种伤口浸润方案，即通过伤口内的导管给予20毫升0.5%布比卡因大剂量推注，并直肠给予吲哚美辛（100毫克）。静脉血浆布比卡因峰值浓度在0.07毫克/升-1至1.14毫克/升-1之间（均值（标准差）为0.47（0.33）毫克/升-1），且在首剂给药后0.25至2小时出现。血浆浓度远低于4毫克/升-1的中毒阈值，且无蓄积现象。该方案提供了满意的镇痛效果。没有伤口感染或毒性迹象。
