Center for Dermatology Research, Departments of Dermatology, Pathology, and Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1071, USA.
Dermatitis. 2010 May-Jun;21(3):148-53.
Reports of vitamin E-induced allergic contact dermatitis (ACD) and frequent use of vitamin-E derivatives (tocopherol, tocopheryl linoleate, tocopherol acetate, etc) in skin care products deserves further investigation into tolerability and suitability of vitamin E in skin care preparations. A PubMed search was conducted to review the prevalence of vitamin E-induced ACD. It revealed 931 cases of vitamin E-induced ACD mainly from one large study. There were no reported deaths and only three patients required hospitalization for treatment. It appears that vitamin E-induced ACD is an uncommon phenomenon; incidence is low despite its widespread use in skin care products. Given its antioxidant and photoprotective properties, vitamin E should remain an ingredient in skin care products.
维生素 E 诱导的过敏性接触性皮炎（ACD）的报道以及维生素 E 衍生物（生育酚、生育酚亚油酸酯、醋酸生育酚等）在护肤品中的频繁使用，值得进一步研究维生素 E 在护肤品中的耐受性和适用性。对 PubMed 进行了检索，以综述维生素 E 诱导的 ACD 的流行率。结果显示，维生素 E 诱导的 ACD 主要来自一项大型研究，共 931 例。没有报告死亡病例，只有 3 例患者因治疗需要住院。维生素 E 诱导的 ACD 似乎是一种罕见的现象；尽管它在护肤品中广泛使用，但发病率很低。鉴于其抗氧化和光保护特性，维生素 E 应仍然是护肤品的一种成分。
