五种近交系小鼠的突触体γ-氨基丁酸摄取与血压之间的关系。

A relationship between synaptosomal GABA uptake and blood pressure in five inbred strains of mice.

作者信息

Tunnicliff G

机构信息

Laboratory of Neurochemistry Indiana University School of Medicine 8600 University Boulevard Evansville, Indiana 47712, USA.

出版信息

Neurochem Int. 1982;4(4):321-7. doi: 10.1016/0197-0186(82)90069-9.

DOI:10.1016/0197-0186(82)90069-9

PMID:20487883

Abstract

Synaptosomal GABA uptake, sodium-dependent GABA binding to synaptic membranes and GABA receptor binding were measured in the cerebral cortex of five inbred strains of mice. These were the SWR/J, BALB/cJ, DBA/1J, C57BL/10J and C3HeB/FeJ strains. A highly significant negative correlation was found to exist between GABA uptake and blood pressure (r = ?0.92). A similarly good negative correlation occurred between sodium-dependent GABA binding and blood pressure. A poor correlation was observed between blood pressure and GABA receptor binding (r = ?0.46). Taken together with other evidence that exists in the literature, these results suggest that in mice blood pressure could be under the influence of the GABA system.

摘要

在五种近交系小鼠的大脑皮层中测量了突触体GABA摄取、钠依赖性GABA与突触膜的结合以及GABA受体结合。这些品系为SWR/J、BALB/cJ、DBA/1J、C57BL/10J和C3HeB/FeJ品系。发现GABA摄取与血压之间存在高度显著的负相关（r = -0.92）。钠依赖性GABA结合与血压之间也出现了类似的良好负相关。观察到血压与GABA受体结合之间的相关性较差（r = -0.46）。结合文献中存在的其他证据，这些结果表明在小鼠中血压可能受GABA系统的影响。