• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Focus on molecules: the cystine/glutamate exchanger (System x(c)(-)).

作者信息

Lim Julie C, Donaldson Paul J

机构信息

Department of Optometry and Vision Science, University of Auckland, Auckland, New Zealand.

出版信息

Exp Eye Res. 2011 Mar;92(3):162-3. doi: 10.1016/j.exer.2010.05.007. Epub 2010 May 19.

DOI:10.1016/j.exer.2010.05.007
PMID:20488177
Abstract
摘要

相似文献

1
Focus on molecules: the cystine/glutamate exchanger (System x(c)(-)).
Exp Eye Res. 2011 Mar;92(3):162-3. doi: 10.1016/j.exer.2010.05.007. Epub 2010 May 19.
2
Identification, Expression, and Roles of the Cystine/Glutamate Antiporter in Ocular Tissues.半胱氨酸/谷氨酸反向转运体在眼部组织中的鉴定、表达和作用。
Oxid Med Cell Longev. 2020 Jun 18;2020:4594606. doi: 10.1155/2020/4594606. eCollection 2020.
3
Mechanisms of oxidative glutamate toxicity: the glutamate/cystine antiporter system xc- as a neuroprotective drug target.氧化谷氨酸毒性的机制:谷氨酸/胱氨酸反向转运蛋白系统 xc-作为神经保护药物靶点。
CNS Neurol Disord Drug Targets. 2010 Jul;9(3):373-82. doi: 10.2174/187152710791292567.
4
The cystine/glutamate antiporter: when too much of a good thing goes bad.胱氨酸/谷氨酸反向转运体:当好事过头就会变坏事。
J Clin Invest. 2014 Aug;124(8):3279-81. doi: 10.1172/JCI76627. Epub 2014 Jul 18.
5
Regulation of the susceptibility to oxidative stress by cysteine availability in pancreatic beta-cells.胰腺β细胞中半胱氨酸可用性对氧化应激易感性的调节。
Am J Physiol Cell Physiol. 2008 Aug;295(2):C468-74. doi: 10.1152/ajpcell.00203.2008. Epub 2008 Jun 4.
6
Stress-induced inhibition of nonsense-mediated RNA decay regulates intracellular cystine transport and intracellular glutathione through regulation of the cystine/glutamate exchanger SLC7A11.应激诱导的无义介导的RNA衰变抑制通过调节胱氨酸/谷氨酸交换体SLC7A11来调节细胞内胱氨酸转运和细胞内谷胱甘肽。
Oncogene. 2015 Aug 6;34(32):4211-8. doi: 10.1038/onc.2014.352. Epub 2014 Nov 17.
7
Dopaminergic neurons of system x(c)⁻-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity.系统 x(c)⁻缺陷型小鼠的多巴胺能神经元对 6-羟多巴胺诱导的毒性具有高度抗性。
FASEB J. 2011 Apr;25(4):1359-69. doi: 10.1096/fj.10-177212. Epub 2010 Dec 29.
8
Cerebral cystine uptake: a tale of two transporters.脑胱氨酸摄取:两种转运蛋白的故事。
Trends Pharmacol Sci. 2002 Jul;23(7):299-302. doi: 10.1016/s0165-6147(02)02060-6.
9
Mapping of the cystine-glutamate exchanger in the mouse eye: a role for xCT in controlling extracellular redox balance.在鼠眼中定位胱氨酸-谷氨酸交换体:xCT 在控制细胞外氧化还原平衡中的作用。
Histochem Cell Biol. 2019 Oct;152(4):293-310. doi: 10.1007/s00418-019-01805-4. Epub 2019 Aug 8.
10
Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc(-), the Na(+)-independent glutamate-cystine exchanger.西格玛1受体通过NRF2信号通路和系统xc(-)(一种不依赖钠离子的谷氨酸-胱氨酸交换体)调节原代视网膜穆勒胶质细胞中的氧化应激反应。
Free Radic Biol Med. 2015 Sep;86:25-36. doi: 10.1016/j.freeradbiomed.2015.04.009. Epub 2015 Apr 25.

引用本文的文献

1
SLC7A11 Inhibitors Represent a Promising Therapeutic Target by Facilitating the Induction of Ferroptosis in Breast Cancer.SLC7A11抑制剂通过促进乳腺癌中铁死亡的诱导而成为一个有前景的治疗靶点。
Int J Mol Cell Med. 2025;14(1):496-516. doi: 10.22088/IJMCM.BUMS.14.1.496.
2
NCAPD3-mediated ferroptosis of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside inhibits proliferation in T47D cells.NCAPD3介导的2,3,5,4'-四羟基二苯乙烯-2-O-β-D-葡萄糖苷铁死亡抑制T47D细胞增殖。
Front Pharmacol. 2025 Jan 29;15:1531220. doi: 10.3389/fphar.2024.1531220. eCollection 2024.
3
Clinicopathological characteristics of invasive stratified mucinous carcinoma of the cervix and the expression and clinical significance of SLC7A11, SLC3A2 and PD-L1.
宫颈浸润性分层黏液癌的临床病理特征及SLC7A11、SLC3A2和PD-L1的表达与临床意义
Front Oncol. 2024 Dec 30;14:1492498. doi: 10.3389/fonc.2024.1492498. eCollection 2024.
4
LncRNA MALAT1 promotes Erastin-induced ferroptosis in the HBV-infected diffuse large B-cell lymphoma.长链非编码 RNA MALAT1 促进乙型肝炎病毒感染的弥漫大 B 细胞淋巴瘤中依维莫司诱导的铁死亡。
Cell Death Dis. 2024 Nov 12;15(11):819. doi: 10.1038/s41419-024-07209-0.
5
Enhanced computed tomography radiomics predicts solute carrier family 7, member 11 in head and neck squamous cell carcinoma.增强计算机断层扫描影像组学预测头颈部鳞状细胞癌中的溶质载体家族7成员11。
Front Genet. 2024 Sep 16;15:1418578. doi: 10.3389/fgene.2024.1418578. eCollection 2024.
6
ATF4 as a Prognostic Marker and Modulator of Glutamine Metabolism in Oestrogen Receptor-Positive Breast Cancer.ATF4作为雌激素受体阳性乳腺癌中谷氨酰胺代谢的预后标志物和调节因子
Pathobiology. 2024;91(6):411-421. doi: 10.1159/000539564. Epub 2024 Jun 11.
7
Ferroptosis: Emerging mechanisms, biological function, and therapeutic potential in cancer and inflammation.铁死亡:癌症与炎症中新兴的机制、生物学功能及治疗潜力
Cell Death Discov. 2024 Jan 24;10(1):45. doi: 10.1038/s41420-024-01825-7.
8
The deubiquitinase ZRANB1 is an E3 ubiquitin ligase for SLC7A11 and regulates ferroptotic resistance.去泛素化酶 ZRANB1 是 SLC7A11 的 E3 泛素连接酶,调节铁死亡抵抗。
J Cell Biol. 2023 Nov 6;222(11). doi: 10.1083/jcb.202212072. Epub 2023 Oct 13.
9
Androgen Receptor Variants Confer Castration Resistance in Prostate Cancer by Counteracting Antiandrogen-Induced Ferroptosis.雄激素受体变异体通过拮抗抗雄激素诱导的铁死亡来赋予前列腺癌去势抵抗性。
Cancer Res. 2023 Oct 2;83(19):3192-3204. doi: 10.1158/0008-5472.CAN-23-0285.
10
The Role of SLC7A11 in Cancer: Friend or Foe?溶质载体家族7成员11(SLC7A11)在癌症中的作用:是友还是敌?
Cancers (Basel). 2022 Jun 22;14(13):3059. doi: 10.3390/cancers14133059.