Division of Respiratory Medicine and Critical Care Medicine, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam Road, Hong Kong Special Administrative Region, Hong Kong, People's Republic of China.
Clin Chest Med. 2010 Jun;31(2):271-85. doi: 10.1016/j.ccm.2010.02.001.
Despite proliferating literature, the exact relationship between obstructive sleep apnea (OSA) and alterations in glucose metabolism is still controversial. There is growing evidence to suggest that OSA imposes adverse effects on glucose metabolism, but the translation into clinical effect is not well delineated. Many potential mechanisms are being explored, mostly relating to peripheral tissue response to insulin and more recently regarding pancreatic beta cell function of insulin secretion. The effect of OSA on glucose metabolism is likely to be influenced by many personal characteristics. Age, degree of adiposity, lifestyle, comorbidities, and even the stage of glucose disorder itself may modify the relationship between OSA and glucose metabolism. In the biologic system of the human body, all these interact to culminate in clinically relevant outcomes.
尽管相关文献不断增加，但阻塞性睡眠呼吸暂停（OSA）与葡萄糖代谢改变的确切关系仍存在争议。越来越多的证据表明 OSA 对葡萄糖代谢有不良影响，但临床效果尚不清楚。许多潜在的机制正在被探索，主要与外周组织对胰岛素的反应有关，最近还与胰岛素分泌的胰岛β细胞功能有关。OSA 对葡萄糖代谢的影响可能受到许多个体特征的影响。年龄、肥胖程度、生活方式、合并症，甚至葡萄糖紊乱本身的阶段都可能改变 OSA 与葡萄糖代谢之间的关系。在人体的生物系统中，所有这些因素相互作用，最终导致临床相关的结果。
