Department of Chemistry, Sciences and Arts Faculty, Celal Bayar University, Muradiye, Manisa, Turkey.
Carbohydr Res. 2010 Jul 19;345(11):1617-21. doi: 10.1016/j.carres.2010.03.043. Epub 2010 Apr 4.
The synthesis of 5-amino-5-deoxy-1,2-O-(S)-trichloroethylidene-beta-L-arabinofuranose and 6-amino-6-deoxy-1,2-O-(S)-trichloroethylidene-alpha-D-glucofuranose is described by a simple three- or four-step route. Antibacterial potency of the new compounds was determined using an inhibition zone diameter test. The results show that these compounds have a broad-spectrum activity against Gram-positive, Gram-negative bacteria and Candida albicans.
5-氨基-5-脱氧-1,2-O-(S)-三氯亚乙基-β-L-阿拉伯呋喃糖和 6-氨基-6-脱氧-1,2-O-(S)-三氯亚乙基-α-D-吡喃葡萄糖苷的合成都可以通过简单的三步或四步路线来实现。采用抑菌圈直径法测定了新化合物的抗菌活性。结果表明，这些化合物对革兰氏阳性菌、革兰氏阴性菌和白色念珠菌具有广谱活性。
