Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, Georgia 30303, United States.
J Psychiatr Res. 2011 Jan;45(1):83-91. doi: 10.1016/j.jpsychires.2010.04.018. Epub 2010 May 20.
Research on comorbidities between substance use disorders and serious mental illnesses would be facilitated by new methods for collecting comprehensive data on substance use, including data on onset, progression, frequency, amounts, and consequential behaviors. Given substantial limitations of available instruments, and a nearly complete absence of methodologies that allow derivation of continuous measures that estimate dose or cumulative exposure, this report describes the development and initial validation of two interviewer-administered, multidimensional measures of substance use, the Lifetime Substance Use Recall (LSUR) and Longitudinal Substance Use Recall for 12 Weeks (LSUR-12) Instruments. Participants (n=60) in an ongoing study of first-episode psychosis were evaluated with the LSUR, LSUR-12, and a number of other concurrent measures pertaining to substance use, substance use disorder diagnoses, select demographic features, and two personality traits. Specific a priori hypothesis tests were selected to demonstrate validity, relying on effect sizes to estimate strengths of association, considering small-to-medium correlations (e.g., ρ) as |.20-.50| and medium-to-large effect sizes as >|.50|. Numerous associations were observed between key nicotine-, alcohol-, and cannabis-related variables from the LSUR and LSUR-12 and scores from other concurrently administered measures. These findings provide a thorough initial validation of scores obtained with the new multidimensional instruments. Although validity of the two new measures of lifetime and past 12-week substance use was demonstrated, empirical data on inter-rater and test-retest reliability are needed. Careful development, and demonstration of psychometric properties, of these and related instruments may advance the fields of addiction and comorbidity research.
研究物质使用障碍和严重精神疾病之间的共病关系将得益于新的方法来收集关于物质使用的综合数据，包括关于发病、进展、频率、数量和后果行为的数据。鉴于现有仪器存在重大局限性，以及几乎完全缺乏可以推导出连续测量值以估计剂量或累积暴露的方法，本报告描述了两种访谈者管理的多维物质使用测量工具的开发和初步验证，即终身物质使用回忆 (LSUR) 和 12 周纵向物质使用回忆 (LSUR-12) 工具。正在进行的首发精神病研究中的参与者 (n=60) 使用 LSUR、LSUR-12 以及其他一些关于物质使用、物质使用障碍诊断、特定人口统计学特征和两种人格特质的同时评估测量工具进行评估。选择了特定的先验假设检验来证明有效性，依靠效应大小来估计关联的强度，考虑小到中等的相关性 (例如，ρ) 为 |.20-.50| 和中到大的效应大小为 >|.50|。LSUR 和 LSUR-12 中的关键尼古丁、酒精和大麻相关变量与同时进行的其他评估测量工具的分数之间观察到了许多关联。这些发现为新多维仪器获得的分数提供了彻底的初步验证。尽管证明了两种新的终生和过去 12 周物质使用的测量工具的有效性，但需要有关评分者间信度和测试重测信度的实证数据。这些和相关工具的仔细开发和心理测量特性的证明可能会推动成瘾和共病研究领域的发展。
