Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran.
Psychiatry Res. 2010 Nov 30;180(1):57-9. doi: 10.1016/j.psychres.2010.04.040. Epub 2010 May 21.
Consanguineous marriage is the union of individuals having at least one common ancestor. It is well established that consanguinity is a potential risk factor for many adverse health outcome of offspring. In the present case-control study we tested the hypothesis of an association between parental consanguinity marriages and risk of offspring substance abuse. The study was performed in Shiraz (Fars province, Iran). Here 156 male drug abusers (case group) and 264 randomly selected healthy blood donors, matched for age and gender as control group, were included in the study. The prevalence of parental consanguineous marriages in the studied sample was 39.1 and 28.0% among cases and controls, respectively. The difference was statistically significant. The substance abusers were more smokers and drinkers compared with the control group. There was significant negative linear trend between drug abuse and level of education. The participants stratified using drinking habits and then the analysis was carried out separately for drinker and non-drinker subjects. Among drinkers, neither before nor after adjusting for smoking status and educational level, parental consanguinity did not show association with risk of substance abuse. Among non-drinkers, after adjusting for smoking status and educational level, parental consanguineous marriage was significantly associated with increased risk of substance abuse. Our study supports a significant relationship between parental consanguinity and drug abuse among non-drinker subjects.
血缘婚姻是指至少有一对共同祖先的个体之间的结合。已有充分证据表明，血缘关系是后代许多不良健康后果的潜在风险因素。在本病例对照研究中，我们检验了父母血缘婚姻与子女物质滥用风险之间存在关联的假设。该研究在设拉子（伊朗法尔斯省）进行。在这项研究中，我们纳入了 156 名男性药物滥用者（病例组）和 264 名随机选择的健康献血者（对照组），按年龄和性别进行匹配。在研究样本中，父母血缘婚姻的流行率分别为病例组的 39.1%和对照组的 28.0%。差异具有统计学意义。与对照组相比，物质滥用者吸烟和饮酒的比例更高。物质滥用与教育程度呈显著负线性趋势。根据饮酒习惯对参与者进行分层，然后分别对饮酒者和非饮酒者进行分析。在饮酒者中，无论是在调整吸烟状况和教育程度之前还是之后，血缘关系与物质滥用风险之间均无关联。在非饮酒者中，在调整吸烟状况和教育程度后，血缘婚姻与物质滥用风险显著相关。我们的研究支持血缘婚姻与非饮酒者物质滥用之间存在显著关系。
