Saadat Mostafa
Department of Biology, College of Sciences, Shiraz University, 71467-13565 Shirazm, Iran.
Egypt J Med Hum Genet. 2022;23(1):8. doi: 10.1186/s43042-022-00218-8. Epub 2022 Jan 21.
Union between second cousins and closer relatives is called consanguineous marriage. Consanguineous marriage is associated with increased risk of autosomal recessive diseases and several multifactorial traits. In order to evaluate the association between prevalence/mortality of COVID-19 and the frequency of consanguineous marriage, the present ecologic study was carried out. For the present study, data of prevalence (per 10 people) and mortality (per 10 people) and number of performed laboratory diagnostic test (per 10 people) of COVID-19 disease at four time points (December 2020; March, August and October 2021) of 65 countries were used.
Univariable correlation and generalized estimating equation analysis were used. In analysis, prevalence and mortality of COVID-19 were used as dependent variables and human development index, number of performed diagnosis test and the mean of inbreeding coefficient (α-value) were introduced into model as covariates, and time point was used as a factor in analysis. The square root (SR) of prevalence ( = 0.008) and SR-mortality ( < 0.001) of COVID-19 negatively associated with the log-transformed of α-value.
The present finding means that in countries with high levels of consanguineous marriages, the prevalence of COVID-19 and mortality due to COVID-19 were lower than countries having low level of marriage with relatives.
二级表亲及更近亲属之间的联姻被称为近亲结婚。近亲结婚与常染色体隐性疾病风险增加以及多种多基因性状有关。为了评估新型冠状病毒肺炎（COVID-19）的患病率/死亡率与近亲结婚频率之间的关联，开展了本生态学研究。在本研究中，使用了65个国家在4个时间点（2020年12月；2021年3月、8月和10月）的COVID-19疾病患病率（每10人）、死亡率（每10人）以及实验室诊断检测次数（每10人）的数据。
采用单变量相关性分析和广义估计方程分析。在分析中，将COVID-19的患病率和死亡率作为因变量，将人类发展指数、诊断检测次数以及近亲繁殖系数均值（α值）作为协变量纳入模型，并将时间点作为分析因素。COVID-19的患病率平方根（SR）（=0.008）和SR-死亡率（<0.001）与α值的对数转换值呈负相关。
本研究结果表明，在近亲结婚率较高的国家，COVID-19的患病率和因COVID-19导致的死亡率低于近亲结婚率较低的国家。
