分裂情感性障碍——一种可能的 MEG 听觉诱发电场生物标志物。
Schizoaffective disorder - a possible MEG auditory evoked field biomarker.
机构信息
MEG Laboratory, Dept of Psychiatry UC Denver School of Medicine, Aurora, CO 80047, USA.
出版信息
Psychiatry Res. 2010 Jun 30;182(3):284-6. doi: 10.1016/j.pscychresns.2010.02.007. Epub 2010 May 21.
Abstract
We recorded magnetoencephalographic auditory steady state responses (SSR) from eight schizoaffective (SAD) subjects and compared the resulting data with previously published findings in persons with schizophrenia (SZ) and controls. SAD subjects exhibited SSR responses similar to controls in the left hemisphere and greater than controls in the right hemisphere, whereas SZ subjects exhibited deficits in both amplitude and phase control in both hemispheres. Our findings suggest preservation of GABAergic inhibitory interneuronal control of layer 3 pyramidal cell activity in primary auditory cortex in SAD.
摘要
我们记录了 8 名分裂情感性障碍（SAD）患者的脑磁图听觉稳态反应（SSR），并将所得数据与先前发表的精神分裂症（SZ）患者和对照组的发现进行了比较。SAD 患者在左半球的 SSR 反应与对照组相似，而在右半球的 SSR 反应大于对照组，而 SZ 患者在两个半球的振幅和相位控制均存在缺陷。我们的研究结果表明，SAD 患者初级听觉皮层中 GABA 能抑制性中间神经元对 3 层锥体细胞活动的控制得以保留。
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