Cox Darren P, Daniels Troy, Jordan Richard C K
Department of Orofacial Sciences, University of California, San Francisco, California 94143-0424, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jul;110(1):79-84. doi: 10.1016/j.tripleo.2010.01.023. Epub 2010 May 21.
The aim of this study was to review the reported cases of solitary fibrous tumor (SFT) in the head and neck and to evaluate this tumor regarding histologic features, treatment, and recurrence. SFT has been described in many extrapleural sites, including the head and neck. Uniform overexpression of CD34 differentiates SFT from other spindle cell neoplasms. SFT is a slow-growing neoplasm that can be successfully treated by complete excision. A rare malignant counterpart has also been described.
In this case series and review of published cases from English-language journals in the National Library of Medicine, we reviewed 142 cases of SFT reported in English-language literature and add 11 new cases. We compared the features reported in the previous publications of SFT from the head and neck with our series, including cases described as malignant or atypical SFT.
Four out of 9 cases with positive margins recurred, whereas only 1 out of 10 cases with atypical or malignant features recurred.
An important finding in SFT of the head and neck is that recurrence appears more related to incomplete excision than to microscopic grade.
本研究旨在回顾已报道的头颈部孤立性纤维瘤（SFT）病例，并从组织学特征、治疗和复发情况方面对该肿瘤进行评估。SFT已在包括头颈部在内的许多胸膜外部位被描述。CD34的一致过表达可将SFT与其他梭形细胞肿瘤区分开来。SFT是一种生长缓慢的肿瘤，可通过完整切除成功治疗。也有罕见的恶性对应物被描述。
在这个病例系列以及对美国国立医学图书馆英文期刊上已发表病例的回顾中，我们回顾了英文文献中报道的142例SFT病例，并新增了11例。我们将先前关于头颈部SFT的出版物中报道的特征与我们的系列病例进行了比较，包括被描述为恶性或非典型SFT的病例。
9例切缘阳性的病例中有4例复发，而10例具有非典型或恶性特征的病例中只有1例复发。
头颈部SFT的一个重要发现是，复发似乎更多与切除不完全有关，而非与显微镜下分级有关。
