Bernardini Francesco P, de Conciliis Carlo, Schneider Susan, Kersten Robert C, Kulwin Dwight R
Department of Ophthalmology, University of Genoa, Genoa, Italy.
Ophthalmology. 2003 Jul;110(7):1442-8. doi: 10.1016/S0161-6420(03)00459-7.
The real incidence of solitary fibrous tumor (SFT) of the orbit is unknown, but it seems that since it was first described in 1994, orbital SFT has been increasingly recognized. We believe that the orbital SFT is a relatively common tumor and that it should be considered in the differential diagnosis of any orbital tumor.
Interventional case series.
Four new cases of orbital SFT.
Four patients affected by solitary fibrous tumor of the orbit are described. One patient experienced a recurrent SFT shortly after initial surgical excision performed elsewhere. Thirty-eight cases have been reported in the literature in 7 years.
The number of orbital SFTs reported has been increasing, reaching an average of more than five tumors reported per year. Since the first orbital SFT was described in 1994, 37 cases have been reported in the literature. We add four new cases in our series, including a recurrent tumor. A total of 42 cases have now been described, eight with recurrences. Malignant transformation occurred in one case.
We believe that before 1994, the diagnosis orbital SFT was confused with other benign orbital tumors, such as fibrous histiocytoma and hemangiopericytoma because of a lack of use of immunohistochemical techniques. This entity should now be considered relatively common and should be included in the differential diagnosis of orbital tumors in any age group. Local recurrences of SFT are possible and usually follow an incomplete initial excision. Recurrent tumors in the orbit have shown the tendency to infiltrate the surrounding tissues and the bone, rendering complete secondary excision more difficult. Recurrent orbital SFT also has the potential for malignant transformation. The treatment of choice of orbital SFT is complete surgical excision and careful follow-up. Considering the more aggressive course followed by recurrent tumor, correct diagnosis and management is essential.
眼眶孤立性纤维瘤（SFT）的实际发病率尚不清楚，但自1994年首次描述以来，眼眶SFT似乎越来越受到认可。我们认为眼眶SFT是一种相对常见的肿瘤，在任何眼眶肿瘤的鉴别诊断中都应予以考虑。
介入性病例系列。
4例眼眶SFT新病例。
描述了4例眼眶孤立性纤维瘤患者。1例患者在别处初次手术切除后不久出现SFT复发。7年内在文献中报道了38例。
报道的眼眶SFT数量一直在增加，平均每年报告超过5例肿瘤。自1994年首次描述眼眶SFT以来，文献中已报道37例。我们的系列中增加了4例新病例，包括1例复发性肿瘤。目前共描述了42例，其中8例复发。1例发生恶性转化。
我们认为在1994年之前，由于缺乏免疫组化技术的应用，眼眶SFT的诊断与其他良性眼眶肿瘤如纤维组织细胞瘤和血管外皮细胞瘤相混淆。现在应认为该实体相对常见，应纳入任何年龄组眼眶肿瘤的鉴别诊断中。SFT可能局部复发，通常发生在初次切除不完全之后。眼眶复发性肿瘤有浸润周围组织和骨骼的倾向，使二次完全切除更加困难。眼眶复发性SFT也有恶性转化的可能。眼眶SFT的治疗选择是完全手术切除并仔细随访。考虑到复发性肿瘤的病程更具侵袭性，正确的诊断和处理至关重要。
