Musculoskeletal Research Group, School of Veterinary Science, University of Liverpool, Leahurst Campus, Neston, Wirral CH64 7TE, UK.
Vet J. 2010 Jul;185(1):36-42. doi: 10.1016/j.tvjl.2010.04.011. Epub 2010 May 21.
Type II collagen is a major component of articular cartilage and its breakdown is a key feature of osteoarthritis. Products of cartilage collagen metabolism can be detected in the blood, synovial fluid and urine. Several biomarker assays have been developed which can be used to measure the synthesis and degradation of collagen, and therefore provide information regarding cartilage turnover. This is the first part of a two-part review and describes the need for accurate, reliable information regarding collagen turnover, the processes by which the biomarker epitopes are generated, their application to the study of both healthy and diseased cartilage and the results of currently published studies, with particular reference to the veterinary species. The second part of the review considers the non-collagenous biomarkers of cartilage matrix turnover.
II 型胶原蛋白是关节软骨的主要成分，其分解是骨关节炎的一个关键特征。软骨胶原代谢产物可在血液、滑液和尿液中检测到。已经开发出几种生物标志物检测方法，可用于测量胶原蛋白的合成和降解，从而提供有关软骨周转率的信息。这是两部分综述的第一部分，描述了对有关胶原转化率的准确、可靠信息的需求，生成生物标志物表位的过程，它们在健康和患病软骨研究中的应用以及当前发表的研究结果，特别参考了兽医物种。综述的第二部分考虑了软骨基质周转率的非胶原蛋白生物标志物。
