Laboratoire Biomnis, 19 Avenue Tony Garnier, 69007 Lyon, France.
Institut Pasteur de Lille, INSERM U629, 1 Rue du Professeur Calmette, 59021 Lille, France.
J Med Microbiol. 2010 Aug;59(Pt 8):984-989. doi: 10.1099/jmm.0.019372-0. Epub 2010 May 20.
Human tuberculosis caused by Mycobacterium microti is rare, but its prevalence and clinical significance may have been underestimated. To the best of our knowledge, 21 cases have been reported in the literature in the last decade. We report six recent pulmonary cases caused by M. microti over a period of 5 years detected in French clinical mycobacteriology laboratories of the hospital network. Our data confirm the potential of M. microti to cause clinical illness in immunocompetent patients. M. microti grew slowly from specimens, delaying the final microbiological diagnosis. Therefore, patients with tuberculosis caused by M. microti could benefit from the use of rapid diagnostic molecular techniques directly on clinical samples. From a review of the literature and this study, a classical antituberculous therapy seems effective in treating patients with M. microti disease.
由微小棒状杆菌引起的人结核病很少见，但它的流行率和临床意义可能被低估了。据我们所知，在过去十年中，文献中有 21 例报告。我们报告了最近 5 年内法国医院网络临床分枝杆菌实验室检测到的 6 例由微小棒状杆菌引起的近期肺部病例。我们的数据证实了微小棒状杆菌在免疫功能正常的患者中引起临床疾病的潜力。微小棒状杆菌从标本中缓慢生长，延迟了最终的微生物学诊断。因此，微小棒状杆菌引起的结核病患者可能受益于直接在临床标本上使用快速诊断分子技术。通过对文献和本研究的回顾，经典的抗结核治疗似乎对治疗微小棒状杆菌病患者有效。
