Department of Intensive Care Medicine, Malmö University Hospital, Lund University, Malmö, Sweden.
Inflamm Res. 2010 Nov;59(11):979-82. doi: 10.1007/s00011-010-0213-5. Epub 2010 May 20.
Recent data suggest that soluble CD40L (sCD40L) plays an important role in murine sepsis. The aim of the present study was to determine plasma levels of CD40L in critically ill patients with systemic inflammatory response syndrome (SIRS) and shock, with and without sepsis.
A prospective observational one-centre cohort study in a mixed-bed ICU of an university hospital. Fifty-three consecutive patients fulfilling the criteria for SIRS with shock as well as seven age-matched controls were included. ELISA was used to determine sCD40L in the plasma.
The level of sCD40L in plasma from healthy controls was 0.18 ± 0.03 ng/ml. It was found that sCD40L levels were significantly higher in patients with non-septic shock (0.72 ± 0.18 ng/ml) and septic shock (0.50 ± 0.1 ng/ml). However, the levels of sCD40L were not different between these two groups of patients, or in those with low and high APACHE scores.
Our data show that sCD40L is increased in patients with shock from septic and non-septic etiologies. However, further studies are needed to delineate the functional significance of sCD40L in the clinical outcome in shock patients.
最近的数据表明可溶性 CD40L（sCD40L）在鼠脓毒症中发挥重要作用。本研究旨在确定全身炎症反应综合征（SIRS）和休克伴或不伴脓毒症的危重病患者血浆中 CD40L 的水平。
一项在一所大学医院混合病床 ICU 进行的前瞻性观察性单中心队列研究。纳入了 53 例符合 SIRS 伴有休克标准的连续患者和 7 例年龄匹配的对照者。采用 ELISA 法测定血浆中 sCD40L 的水平。
健康对照组血浆中 sCD40L 的水平为 0.18±0.03ng/ml。结果发现，非脓毒性休克患者（0.72±0.18ng/ml）和脓毒性休克患者（0.50±0.1ng/ml）的 sCD40L 水平明显升高。然而，这两组患者之间 sCD40L 的水平没有差异，也没有差异在低和高 APACHE 评分的患者之间。
我们的数据表明，脓毒症和非脓毒症病因引起的休克患者 sCD40L 增加。然而，需要进一步的研究来阐明 sCD40L 在休克患者临床转归中的功能意义。
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