植物半胱氨酸蛋白酶诱发瘙痒，激活蛋白酶激活受体。
Plant cysteine proteases that evoke itch activate protease-activated receptors.
机构信息
Massachusetts General Hospital Cutaneous Biology Research Center, Charlestown, MA 02129, U.S.A.
出版信息
Br J Dermatol. 2010 Sep;163(3):532-5. doi: 10.1111/j.1365-2133.2010.09862.x. Epub 2010 Aug 12.
Abstract
BACKGROUND
Bromelain, ficin and papain are cysteine proteases from plants that produce itch upon injection into skin. Their mechanism of action has not been considered previously.
OBJECTIVES
To determine the mechanism by which these proteases function.
METHODS
The ability of these proteases to activate protease-activated receptors was determined by ratiometric calcium imaging.
RESULTS
We show here that bromelain, ficin and papain activate protease-activated receptors 2 and 4.
CONCLUSIONS
Bromelain, ficin and papain function as signalling molecules and activate protease-activated receptors. Activation of these receptors is the likely mechanism by which these proteases evoke itch.
摘要
背景
菠萝蛋白酶、ficin 和木瓜蛋白酶是植物来源的半胱氨酸蛋白酶，注射到皮肤中会引起瘙痒。它们的作用机制以前没有被考虑过。
目的
确定这些蛋白酶的作用机制。
方法
通过比率钙成像来确定这些蛋白酶激活蛋白酶激活受体的能力。
结果
我们在这里表明，菠萝蛋白酶、ficin 和木瓜蛋白酶激活蛋白酶激活受体 2 和 4。
结论
菠萝蛋白酶、ficin 和木瓜蛋白酶作为信号分子发挥作用，激活蛋白酶激活受体。这些蛋白酶引起瘙痒的可能机制是激活这些受体。
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