瘙痒的外周机制。
Peripheral Mechanisms of Itch.
机构信息
Center for the Study of Itch & Sensory Disorders, Department of Anesthesiology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, USA.
Center for the Study of Itch & Sensory Disorders, Department of Anesthesiology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, USA.
出版信息
J Invest Dermatol. 2022 Jan;142(1):31-41. doi: 10.1016/j.jid.2021.10.024. Epub 2021 Nov 24.
Abstract
Itch is a universally experienced sensation, and chronic itch can be as diabolically debilitating as pain. Recent advances have not only identified the neuronal itch sensing circuitry, but also have uncovered the intricate interactions between skin and immune cells that work together with neurons to identify itch-inducing irritants. In this review, we will summarize the fundamental mechanisms of acute itch detection in the skin, as well as highlight the recent discoveries relating to this topic.
摘要
痒是一种普遍的感觉体验，慢性痒可能像疼痛一样使人衰弱。最近的进展不仅确定了神经元瘙痒感应回路，还揭示了皮肤和免疫细胞之间的复杂相互作用，这些相互作用与神经元一起识别引起瘙痒的刺激物。在这篇综述中，我们将总结皮肤中急性瘙痒检测的基本机制，并强调与这一主题相关的最新发现。
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