异烟肼对扑热息痛代谢的抑制作用。
Inhibition of the metabolism of paracetamol by isoniazid.
作者信息
Epstein M M, Nelson S D, Slattery J T, Kalhorn T F, Wall R A, Wright J M
机构信息
Department of Pharmacology & Therapeutics, University of Bristish Columbia, Vancouver, Canada.
出版信息
Br J Clin Pharmacol. 1991 Feb;31(2):139-42. doi: 10.1111/j.1365-2125.1991.tb05501.x.
Abstract
- The effect of isoniazid given daily for 7 days on paracetamol (acetaminophen) kinetics and metabolism was studied in 10 healthy volunteers. Paracetamol, 500 mg, was given before isoniazid, on day 7 of isoniazid administration, and 2 days after the last dose of isoniazid. 2. On day 7, isoniazid markedly inhibited the formation clearance of the glutathione and catechol metabolites by 69.7% and 62.2%, respectively. Total paracetamol clearance was lowered by 15.2%. There was no effect of isoniazid on the non-oxidative pathways of paracetamol elimination. 3. Two days after isoniazid was discontinued, paracetamol metabolism had returned to pre-isoniazid values.
摘要
- 在10名健康志愿者中研究了连续7天每日给予异烟肼对扑热息痛（对乙酰氨基酚）动力学和代谢的影响。在给予异烟肼前、异烟肼给药第7天以及最后一剂异烟肼后2天，均给予500毫克扑热息痛。2. 在第7天，异烟肼显著抑制了谷胱甘肽和儿茶酚代谢物的生成清除率，分别降低了69.7%和62.2%。扑热息痛的总清除率降低了15.2%。异烟肼对扑热息痛非氧化代谢途径没有影响。3. 停用异烟肼两天后，扑热息痛代谢已恢复到异烟肼给药前的水平。
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本文引用的文献
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