氯喹对扑热息痛处置和动力学的影响。
The effect of chloroquine on paracetamol disposition and kinetics.
作者信息
Adjepon-Yamoah K K, Woolhouse N M, Prescott L F
出版信息
Br J Clin Pharmacol. 1986 Mar;21(3):322-4. doi: 10.1111/j.1365-2125.1986.tb05197.x.
The effect of chloroquine on paracetamol kinetics and disposition was investigated in six healthy male Ghanaian volunteers. Chloroquine administration shortened the time taken to reach peak plasma paracetamol concentration (tmax) in five of the volunteers. Peak plasma paracetamol concentration (Cmax) was significantly increased by chloroquine administration. The area under the plasma paracetamol concentration-time curve was also significantly increased by chloroquine administration. There was, however, no effect of chloroquine on paracetamol metabolism.
在六名健康的加纳男性志愿者中研究了氯喹对扑热息痛动力学和处置的影响。给予氯喹后，五名志愿者达到血浆扑热息痛峰值浓度（tmax）的时间缩短。给予氯喹后，血浆扑热息痛峰值浓度（Cmax）显著升高。给予氯喹后，血浆扑热息痛浓度-时间曲线下面积也显著增加。然而，氯喹对扑热息痛代谢没有影响。
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