一种用于雾化溶液的非支气管收缩性抑菌防腐剂。
A non-bronchoconstrictor, bacteriostatic preservative for nebuliser solutions.
作者信息
Summers Q A, Nesbit M R, Levin R, Holgate S T
机构信息
Immunopharmacology Group, University of Southampton.
出版信息
Br J Clin Pharmacol. 1991 Feb;31(2):204-6. doi: 10.1111/j.1365-2125.1991.tb05517.x.
We have studied the bacteriostatic and airways effects of the preservatives chlorocresol and chlorbutol, to assess if they may be safely used in nebuliser solutions. The bacteriostatic study was carried out according to standard techniques, and the preservatives were able to inhibit the growth of a range of bacteria and yeasts for a period of 28 days. The airways effects were studied in eight asthmatic subjects, who were challenged with either the preservatives or saline (as placebo). Pulmonary function was followed as FEV1 for 60 min after inhalation, and there was no change in FEV1 following inhalation. We conclude that these preservatives may be used safely in nebuliser solutions.
我们研究了防腐剂氯甲酚和三氯叔丁醇的抑菌作用及对气道的影响，以评估它们是否可安全用于雾化液中。抑菌研究按照标准技术进行，这些防腐剂能够在28天内抑制多种细菌和酵母菌的生长。在8名哮喘患者中研究了对气道的影响，这些患者分别接受防腐剂或生理盐水（作为安慰剂）激发试验。吸入后随访60分钟的第一秒用力呼气容积（FEV1）来观察肺功能，吸入后FEV1没有变化。我们得出结论，这些防腐剂可安全用于雾化液中。
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