Department of Psychology, University of Helsinki, Helsinki, Finland.
Psychiatry Res. 2010 Sep 30;179(2):226-30. doi: 10.1016/j.psychres.2009.08.024. Epub 2010 May 20.
Although a suboptimal prenatal environment has been linked with schizophrenia and depression, possible associations with personality disorders remain unclear. The aim of this study was to examine the associations of body size at birth and length of gestation with hospitalization for personality disorders in a cohort study of 6506 men and 5857 women born in Helsinki, Finland, between 1934 and 1944. International Classification of Diseases (-8, -9, -10) diagnoses of personality disorders were extracted from the national Finnish Hospital Discharge Register since 1969. 102 men and 80 women had been hospitalized due to any personality disorder. 41 men and 30 women had dramatic personality disorders. Among men, head circumference showed an inverse J-shaped, nonlinear association with hospitalization for personality disorders. Men with a small head circumference were at increased risk. Also in men, a smaller head-to-length ratio linearly predicted personality disorders. Among women, a smaller placental area predicted increased risk of hospitalization for dramatic personality disorders. Vulnerability to personality disorders may be programmed during fetal life.
虽然产前环境不佳与精神分裂症和抑郁症有关，但与人格障碍的可能关联尚不清楚。本研究旨在通过对芬兰赫尔辛基出生于 1934 年至 1944 年间的 6506 名男性和 5857 名女性的队列研究，检查出生时的体型和妊娠期与人格障碍住院之间的关联。自 1969 年以来，人格障碍的国际疾病分类（-8、-9、-10）诊断已从国家芬兰住院登记处提取。102 名男性和 80 名女性因任何人格障碍住院。41 名男性和 30 名女性患有戏剧性人格障碍。在男性中，头围与人格障碍住院呈反 J 形非线性关联。头围较小的男性患病风险增加。同样在男性中，头长比越小，人格障碍的线性预测风险越大。在女性中，胎盘面积较小预示着戏剧性人格障碍住院的风险增加。人格障碍的易感性可能在胎儿期就已经编程。
