Institute of Behavioural Sciences, University of Helsinki, Siltavuorenpenger 1A, PO Box 9, FI 00014, University of Helsinki, Finland.
J Pers Disord. 2011 Oct;25(5):620-33. doi: 10.1521/pedi.2011.25.5.620.
This study examined the associations between infant and childhood growth and severe personality disorders. Among 4,689 men and 4,200 women of the Helsinki Birth Cohort Study 1934-1944, 81 men and 68 women had been hospitalized with an ICD (-8, -9, -10) diagnosis of personality disorder in adulthood. Among men, slower gain in BMI between birth and 6 months, faster gain in weight and BMI between 6 months and 1 year, and slower gains in them between 7 and 11 years of age predicted an increased risk of hospitalization for personality disorders. Thinness at 6 months and again at 11 years also showed significant association with personality disorders among men. Among women, slower gain in height between 2 and 7 years predicted hospitalization for personality disorders. Our findings show the importance of early growth as a vulnerability factor of personality disorders severe enough to justify hospitalization.
这项研究考察了婴儿期和儿童期生长与严重人格障碍之间的关联。在赫尔辛基出生队列研究 1934-1944 年的 4689 名男性和 4200 名女性中，有 81 名男性和 68 名女性在成年后因人格障碍被 ICD（-8、-9、-10）诊断住院。在男性中，出生至 6 个月期间 BMI 增长缓慢、6 个月至 1 岁期间体重和 BMI 增长较快、7 至 11 岁期间增长较慢，这些情况预示着患人格障碍住院的风险增加。6 个月和 11 岁时的消瘦也与男性的人格障碍有显著关联。在女性中，2 至 7 岁期间身高增长缓慢与人格障碍住院有关。我们的研究结果表明，早期生长作为一种易患人格障碍的脆弱因素的重要性，这种人格障碍严重到足以需要住院治疗。
