Newton D W, McMullen J N, Becker C H
J Pharm Sci. 1977 Sep;66(9):1327-30. doi: 10.1002/jps.2600660931.
Medicated and unmedicated microglobules prepared from complex coacervates of Type A gelatin and acacia were recovered as water-insoluble powders consisting of discrete units, which were spontaneously revertible to highly disperse systems when suspended in water or physiological electrolyte solutions. Spherical microglobules containing up to 15% (w/w) sulfamerazine had a nominal diameter of 30 micron in aqueous suspension. Larger but irregularly shaped products containing up to 45% (w/w) sulfamerazine were also recovered. The relationships of the weight of sulfamerazine added per coacervate batch to weight yield and percent (w/w) included sulfamerazine of the microglobules were both linear.
由A型明胶和阿拉伯胶的复合凝聚物制备的含药和不含药微球以水不溶性粉末形式回收，该粉末由离散单元组成，当悬浮于水或生理电解质溶液中时可自发恢复为高度分散体系。在水悬浮液中，含有高达15%（w/w）磺胺甲基嘧啶的球形微球标称直径为30微米。还回收了含有高达45%（w/w）磺胺甲基嘧啶的更大但形状不规则的产物。每批凝聚物中添加的磺胺甲基嘧啶重量与微球的重量产率和含磺胺甲基嘧啶百分比（w/w）之间的关系均为线性。
