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果胶 - 明胶复合凝聚物I:微球大小、形态及作为水分散性粉末回收率的决定因素

Pectin-gelatin complex coacervates I: Determinants of microglobule size, morphology, and recovery as water-dispersible powders.

作者信息

McMullen J N, Newton D W, Becker C H

出版信息

J Pharm Sci. 1982 Jun;71(6):628-33. doi: 10.1002/jps.2600710608.

Abstract

The pectin-gelatin complex coacervate system was evaluated and characterized. The effects of final pH, mixing pH, colloid ratio, and solution concentration were investigated. A recovery procedure yielding microglobules of a controlled and uniform size in dry powder form which were readily revertible in water to a polydispersed suspension was developed. The effect of various conditions and additives on the recovery morphology and size of the microglobules was evaluated.

摘要

对果胶-明胶复合凝聚系统进行了评估和表征。研究了最终pH值、混合pH值、胶体比例和溶液浓度的影响。开发了一种回收程序,可得到干粉形式的大小可控且均匀的微球,这些微球在水中可轻易恢复为多分散悬浮液。评估了各种条件和添加剂对微球回收形态和大小的影响。

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