Paracelsus Society for Balneology and Iodine Research, Kurpromenade 1, 4540, Bad Hall, Austria.
Graefes Arch Clin Exp Ophthalmol. 2010 Nov;248(11):1639-46. doi: 10.1007/s00417-010-1416-8. Epub 2010 May 23.
Environmental oxidative stress changing the properties of the tear fluid can lead to keratoconjunctivitis sicca (dry eye syndrome). The aim of this study was to determine whether iodide iontophoresis influences the antioxidative capacity (ACW = water soluble antioxidative capacity) of the tear fluid, and to compare iodide iontophoresis with other balneotherapeutic measures.
This prospective study evaluated 92 patients in four groups. Twenty-four patients were treated with iodide iontophoresis, 24 with other balneotherapeutic methods. Twenty-five patients received iodide iontophoresis combined with other balneotherapeutic methods and 21 persons received no treatment (control). Unstimulated tear fluid, serum and urine were collected. ACW was determined photochemically in tear fluid and serum; iodine was measured in urine photometrically.
Iodide iontophoresis increases the ACW of the tear fluid but not the ACW of the serum. Other iodine therapies increase the ACW in serum but not in tear fluid. Iodine excretion in urine was increased in all treated groups compared to the control.
The increase of ACW in tear fluid after iodide iontophoresis can support the defense mechanism of the eye against oxidative influence effects, which may alleviate the symptoms of keratoconjunctivitis sicca.
环境氧化应激改变泪液特性可导致干眼症（干眼病综合征）。本研究旨在确定碘离子电泳是否会影响泪液的抗氧化能力（ACW=水溶性抗氧化能力），并将碘离子电泳与其他矿泉治疗方法进行比较。
这项前瞻性研究评估了四组中的 92 名患者。24 名患者接受碘离子电泳治疗，24 名患者接受其他矿泉治疗方法。25 名患者接受碘离子电泳联合其他矿泉治疗方法，21 名患者未接受治疗（对照组）。采集非刺激性泪液、血清和尿液。通过光化学法测定泪液和血清中的 ACW；通过分光光度法测定尿液中的碘。
碘离子电泳增加了泪液的 ACW，但不增加血清的 ACW。其他碘治疗方法增加了血清中的 ACW，但不增加泪液中的 ACW。与对照组相比，所有治疗组的尿碘排泄均增加。
碘离子电泳后泪液 ACW 的增加可以支持眼睛对抗氧化影响的防御机制，从而可能缓解干眼症的症状。
