Department of Pathology, State Key Laboratory of Tumor Biology, Xi-Jing Hospital, Xi'an, Shaanxi, China.
Neuropathology. 2011 Feb;31(1):66-70. doi: 10.1111/j.1440-1789.2010.01125.x.
Both chordoma and Rathke's cleft cyst are relatively rare diseases in the central nervous system. In this paper we report the first case of a chordoma coexisting with a Rathke's cleft cyst. A 49-year-old man presented with a 19-month history of distending pain, movement dysfunction and diplopia of the left eye. The preoperative diagnosis was consistent with chordoma with cystic change. Final pathological diagnosis of chordoma coexisting with Rathke's cleft cyst was made according to histological and immunohistochemical studies and the clinical and radiological features are discussed. Considering the close relationship between the notochordal tissue and Rathke's pouch during early embryogenic development, a possible mechanism is also discussed with the literature review.
脊索瘤和 Rathke 氏裂囊肿都是中枢神经系统中相对罕见的疾病。本文报道首例脊索瘤合并 Rathke 氏裂囊肿。一名 49 岁男性，表现为左眼进行性视物重影伴胀痛 19 个月，术前诊断考虑为脊索瘤伴囊性变。最终的病理诊断为脊索瘤合并 Rathke 氏裂囊肿，组织学和免疫组化研究以及临床和影像学特征进行了讨论。鉴于脊索组织和 Rathke 氏囊在胚胎早期发育过程中的密切关系，也结合文献探讨了可能的发病机制。
