Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.
Int J Obes (Lond). 2010 Oct;34(10):1475-9. doi: 10.1038/ijo.2010.101. Epub 2010 May 25.
The function that the timing of introduction of solid foods may have in the development of child obesity has not been adequately explored, either as a potential confounder of the relationship between breastfeeding and child obesity, or as an independent modifiable risk factor.
To determine the association between infant feeding practices and child overweight/obesity.
Six hundred and twenty subjects were recruited antenatally from 1990 to 1994. A total of 18 telephone interviews over the first 2 years of life recorded infant feeding practices. At mean age of 10 years, height and weight were measured for 307 subjects. Multiple logistic regression was used to determine whether infant feeding practices (duration of exclusive and any breastfeeding, and age at introduction of solid foods) were associated with odds of being overweight/obese (internationally age- and sex-standardized body mass index category) at age 10 years, after adjustment for confounders.
Delayed introduction of solid foods was associated with reduced odds of being overweight/obese at age 10 years, after controlling for socioeconomic status, parental smoking and childcare attendance (adjusted odds ratio (aOR)=0.903 per week, 95% CI=0.841-0.970, P=0.005). Antenatal parental smoking was associated with overweight/obesity at age 10 years (aOR=3.178, 95% CI=1.643-6.147, P=0.001). Duration of exclusive or any breastfeeding was not associated with the outcome.
Delayed introduction of solids is associated with reduced odds of child overweight/obesity. Wider promotion of current infant feeding guidelines could have a significant impact on the rates of child overweight and obesity.
固体食物引入时间对儿童肥胖发展的影响，无论是作为母乳喂养与儿童肥胖关系的潜在混杂因素，还是作为独立的可改变的危险因素，都尚未得到充分探讨。
确定婴儿喂养方式与儿童超重/肥胖的关系。
1990 年至 1994 年期间，620 名受试者在产前被招募。在生命的头 2 年中，通过总共 18 次电话访谈记录了婴儿的喂养方式。在 307 名受试者中，有 10 岁时的身高和体重测量数据。采用多因素逻辑回归来确定婴儿喂养方式（纯母乳喂养和任何形式母乳喂养的持续时间以及固体食物引入的年龄）是否与 10 岁时超重/肥胖的几率（国际年龄和性别标准化的体重指数类别）相关，在调整混杂因素后。
在控制社会经济地位、父母吸烟和儿童保育出勤率后，固体食物引入时间延迟与 10 岁时超重/肥胖的几率降低相关（调整后的优势比（aOR）=每周 0.903，95%置信区间（CI）=0.841-0.970，P=0.005）。产前父母吸烟与 10 岁时的超重/肥胖相关（aOR=3.178，95%CI=1.643-6.147，P=0.001）。纯母乳喂养或任何形式母乳喂养的持续时间与结果无关。
固体食物引入时间延迟与儿童超重/肥胖几率降低相关。更广泛地推广当前的婴儿喂养指南可能会对儿童超重和肥胖的发生率产生重大影响。
