Lejoyeux M, Dubois G, Turpin J C, Baumann N, Lempérière T
Service de Psychiatrie, Hôpital Louis Mourier, Colombes.
Encephale. 1991 Mar-Apr;17(2):87-92.
After a clinical and biological description of arylsulfatase A and metachromatic leucodystrophy, we present the results of a study of leucocyte arylsulfatase A in a population of 22 adult psychotic inpatients. The patients, clinically defined, filled the criteria of DSM III of schizophrenic disorders. All of them were treated by neuroleptics. None of these 22 patients showed a level of arylsulfatase A different from the range of 27 healthy adult controls. These results differ from those of most precedent studies of arylsulfatase A in "psychiatric populations". Some explanations of this difference are suggested. The concept of "purely psychiatric" form of adult metachromatic leucodystrophy is discussed.
在对芳基硫酸酯酶A和异染性脑白质营养不良进行临床和生物学描述之后，我们呈现了对22名成年精神病住院患者白细胞芳基硫酸酯酶A的研究结果。这些患者根据临床定义符合精神分裂症障碍的《精神疾病诊断与统计手册》第三版标准。他们均接受抗精神病药物治疗。这22名患者中没有一人的芳基硫酸酯酶A水平与27名健康成年对照的范围不同。这些结果与之前大多数关于“精神病群体”中芳基硫酸酯酶A的研究结果不同。文中提出了对此差异的一些解释。还讨论了成人异染性脑白质营养不良“纯精神性”形式的概念。
