Segal Michael, Avital Avi, Berstein Severina, Derevenski Andrei, Sandbank Sergio, Weizman Abraham
Flügelman's (Mazra) Mental Health Medical Center, Doar Na Ashrat, 25201, Acre, Israel.
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):378-82. doi: 10.1016/j.pnpbp.2006.09.016. Epub 2006 Nov 14.
There is evidence for the involvement of the endocrine system in schizophrenia. This involment was widely investigated in female patients. In the current study, we examined prolactin and estradiol serum levels in hospitalized unmedicated men with first-episode and recurrent schizophrenia and then tested possible correlation with various subtypes of the disease. In addition, the estradiol and prolactin levels were compared with a healthy control group. The serum samples were assessed the morning following admission in fifty-seven schizophrenia male patients. There was a significant difference in prolactin serum levels between the paranoid and "nonparanoid" schizophrenia subgroups. However, no significant differences were found in estradiol serum levels between schizophrenia subtypes or between the patients and their healthy counterparts. Finally, a significant and positive correlation was found between the prolactin and estradiol levels in the paranoid subgroup alone. Thus, it appears that low estradiol levels are associated with low prolactin levels, alleged hyperdopaminergic tone and psychotic breakdown in paranoid schizophrenia. The results of the present study further support our previous report of the association between prolactin serum levels and the schizophrenia cluster subtypes, indicating a different dopaminergic activity for the various forms of the disease.
有证据表明内分泌系统与精神分裂症有关。这种关联在女性患者中得到了广泛研究。在本研究中，我们检测了首次发作和复发的未用药住院男性精神分裂症患者的催乳素和雌二醇血清水平，然后测试了它们与该疾病不同亚型之间的可能相关性。此外，还将雌二醇和催乳素水平与健康对照组进行了比较。在57名男性精神分裂症患者入院后的早晨采集血清样本进行评估。偏执型和“非偏执型”精神分裂症亚组之间的催乳素血清水平存在显著差异。然而，精神分裂症各亚型之间或患者与其健康对照者之间的雌二醇血清水平未发现显著差异。最后，仅在偏执型亚组中发现催乳素和雌二醇水平之间存在显著正相关。因此，似乎低雌二醇水平与低催乳素水平、所谓的高多巴胺能状态以及偏执型精神分裂症的精神病性发作有关。本研究结果进一步支持了我们之前关于催乳素血清水平与精神分裂症聚类亚型之间关联的报告，表明该疾病的不同形式具有不同的多巴胺能活性。
