Department of Pediatrics, Nippon Medical School, Chiba-Hokusoh Hospital, Chiba-Pre., Japan.
Scand J Immunol. 2010 Jun;71(6):447-51. doi: 10.1111/j.1365-3083.2010.02391.x.
We identify possible differences in the cytokine/chemokine profiles in cerebrospinal fluid (CSF) from children with encephalopathy and febrile seizure. Interleukin (IL)-1beta, 2, 4, 5, 6, 7, 8, 10, 12, 13, 17, interferon-gamma, tumour necrosis factor-alpha, granulocyte colony-stimulating factor, granulocyte monocyte colony-stimulating factor, monocyte chemoattractant protein-1 and macrophage inflammatory protein-1beta were measured simultaneously in CSF supernatants from children with encephalopathy (n = 8), febrile seizure (n = 16) and fever without neurological complications (n = 8). IL-8 in CSF from children with encephalopathy was significantly elevated compared to that in CSF from children with febrile seizure and fever without neurological complications. IL-8 in CSF was also higher than serum IL-8, suggesting that increased IL-8 was generated from glia cells or astrocytes, not by leakage from serum. Increased IL-8 in CSF in encephalopathy may protect against severe brain damage.
我们发现，患有脑病和热性惊厥的儿童的脑脊液（CSF）中细胞因子/趋化因子谱可能存在差异。白细胞介素（IL）-1β、2、4、5、6、7、8、10、12、13、17、干扰素-γ、肿瘤坏死因子-α、粒细胞集落刺激因子、粒细胞-巨噬细胞集落刺激因子、单核细胞趋化蛋白-1 和巨噬细胞炎症蛋白-1β在脑病患儿（n=8）、热性惊厥患儿（n=16）和无神经系统并发症发热患儿（n=8）的脑脊液上清液中同时进行了检测。与热性惊厥患儿和无神经系统并发症发热患儿的脑脊液相比，脑病患儿脑脊液中的 IL-8 显著升高。脑病患儿脑脊液中的 IL-8 也高于血清中的 IL-8，提示增加的 IL-8 是由神经胶质细胞或星形胶质细胞产生的，而不是从血清中漏出的。脑病患者脑脊液中 IL-8 的增加可能有助于防止严重的脑损伤。
