Department of Physiology & Biophysics, Weill Medical College of Cornell University, New York, NY, USA.
Bioinformatics. 2010 Jul 15;26(14):1804-5. doi: 10.1093/bioinformatics/btq264. Epub 2010 May 25.
Rapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically. Based on an ontology derived from a community dialog involving colleagues using experimental and computational methodologies, we developed the GPCR-Oligomerization Knowledge Base (GPCR-OKB). GPCR-OKB is a system that supports browsing and searching for GPCR oligomer data. Such data were manually derived from the literature. While focused on GPCR oligomers, GPCR-OKB is seamlessly connected to GPCRDB, facilitating the correlation of information about GPCR protomers and oligomers.
The GPCR-OKB web application is freely available at http://www.gpcr-okb.org
过去几年中,关于 G 蛋白偶联受体 (GPCR) 二聚体/寡聚体的可用数据迅速增加,这就需要有一种有效的系统来电子组织这些信息。基于一个从涉及使用实验和计算方法学的同事的社区对话中得出的本体,我们开发了 GPCR 寡聚知识库 (GPCR-OKB)。GPCR-OKB 是一个支持浏览和搜索 GPCR 寡聚体数据的系统。这些数据是从文献中手动推导出来的。虽然专注于 GPCR 寡聚体,但 GPCR-OKB 与 GPCRDB 无缝连接,方便了 GPCR 原体和寡聚体信息的关联。
GPCR-OKB 网络应用程序可在 http://www.gpcr-okb.org 免费获得。