鞘内注射后严重痉挛患者脑脊液中巴氯芬的水平。
CSF baclofen levels after intrathecal administration in severe spasticity.
作者信息
Sallerin-Caute B, Lazorthes Y, Monsarrat B, Cros J, Bastide R
机构信息
Laboratoire de Pharmacie Galénique, Faculté des Sciences Pharmaceutiques, Toxicologie Fondamentales du CNRS, Toulouse, France.
出版信息
Eur J Clin Pharmacol. 1991;40(4):363-5. doi: 10.1007/BF00265844.
The pharmacokinetic parameters in the CSF of baclofen given to 4 patients as an intrathecal bolus are reported. Considerable inter-individual variability in the parameters was observed. The elimination half-life ranged from 0.9 to 5 h and the clearance from 0.013 to 0.08 l.h-1. In order to optimize treatment, it is suggested that CSF baclofen levels be matched to changes in Hoffman's monosynaptic reflex (H reflex).
报告了4例患者鞘内注射巴氯芬后脑脊液中的药代动力学参数。观察到这些参数存在相当大的个体间差异。消除半衰期为0.9至5小时，清除率为0.013至0.08升·小时⁻¹。为优化治疗，建议使脑脊液中巴氯芬水平与霍夫曼单突触反射（H反射）的变化相匹配。
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