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Association of genetic variation in the transforming growth factor beta-1 gene with serum levels and risk of colorectal neoplasia.转化生长因子β-1基因的遗传变异与血清水平及结直肠肿瘤发生风险的关联
Cancer Res. 2008 Feb 15;68(4):1236-44. doi: 10.1158/0008-5472.CAN-07-2144.
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Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition.欧洲癌症与营养前瞻性调查中血清C肽、胰岛素样生长因子结合蛋白-1和胰岛素样生长因子结合蛋白-2与结肠癌和直肠癌风险的关系
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7
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8
Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps.胰岛素样生长因子-I和胰岛素与腺瘤性息肉的存在及进展相关。
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Insulin, insulin-like growth factors and colon cancer: a review of the evidence.胰岛素、胰岛素样生长因子与结肠癌：证据综述
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血浆 C 肽和 IGFBP-1 水平与多种族人群结直肠腺瘤风险的相关性。

Associations of plasma C-peptide and IGFBP-1 levels with risk of colorectal adenoma in a multiethnic population.

机构信息

Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA.

出版信息

Cancer Epidemiol Biomarkers Prev. 2010 Jun;19(6):1471-7. doi: 10.1158/1055-9965.EPI-10-0128. Epub 2010 May 25.

DOI:10.1158/1055-9965.EPI-10-0128
PMID:20501760
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2882992/
Abstract

BACKGROUND

Circulating levels of insulin and insulin-like growth factor (IGF) hormones have been associated with colorectal cancer risk, but few studies have examined their associations with colorectal adenoma.

METHODS

We measured plasma C-peptide, a marker of insulin secretion, and IGF hormones in a case-control study of 554 pathologically confirmed, first-time adenoma cases and 786 controls with normal endoscopy among Caucasians, Japanese, and Native Hawaiians in Hawaii.

RESULTS

High plasma levels of C-peptide were statistically significantly associated with risk of colorectal adenoma [multivariate odds ratio (95% confidence interval) for increasing quartiles: 1.0, 0.91 (0.65-1.27), 1.21 (0.86-1.71), and 1.79 (1.23-2.60); P(trend) = 0.0002]. We also observed a statistically significant inverse association between levels of plasma IGF binding protein-1 (IGFBP-1) and adenoma risk [1.0, 0.97 (0.70-1.34), 0.82 (0.58-1.15), and 0.47 (0.32-0.70); P(trend) <0.0001]. These associations remain significant after adjusting for each other and were not confounded by known risk factors. IGF-I, IGFBP-3, body mass index, and waist or hip circumference were not independently associated with adenoma risk.

CONCLUSION

These results provide evidence for an association of insulin and IGFBP-1 levels with colorectal adenoma.

IMPACT

This study suggests that hyperinsulinemia and IGF hormones may act as etiologic factors in colorectal carcinogenesis, as early as during adenoma formation.

摘要

背景

循环胰岛素和胰岛素样生长因子（IGF）水平与结直肠癌风险相关，但很少有研究检查它们与结直肠腺瘤的关系。

方法

我们在一项病例对照研究中测量了 554 例经病理证实的首次腺瘤病例和 786 例内镜正常的对照者的血浆 C 肽，这是胰岛素分泌的标志物，以及白种人、日本人、夏威夷原住民中的 IGF 激素。

结果

高血浆 C 肽水平与结直肠腺瘤风险呈统计学显著相关[递增四分位数的多变量优势比（95%置信区间）：1.0、0.91（0.65-1.27）、1.21（0.86-1.71）和 1.79（1.23-2.60）；P（趋势）=0.0002]。我们还观察到血浆 IGF 结合蛋白-1（IGFBP-1）水平与腺瘤风险呈统计学显著负相关[1.0、0.97（0.70-1.34）、0.82（0.58-1.15）和 0.47（0.32-0.70）；P（趋势）<0.0001]。这些关联在相互调整后仍然显著，并且不受已知危险因素的混杂。IGF-I、IGFBP-3、体重指数、腰围或臀围与腺瘤风险无关。

结论

这些结果为胰岛素和 IGFBP-1 水平与结直肠腺瘤之间的关系提供了证据。

影响

这项研究表明，高胰岛素血症和 IGF 激素可能在结直肠癌变过程中作为病因因素发挥作用，早在腺瘤形成时就可能发挥作用。