Muc-Wierzgoń Małgorzata, Nowakowska-Zajdel Ewa, Dzięgielewska-Gęsiak Sylwia, Kokot Teresa, Klakla Katarzyna, Fatyga Edyta, Grochowska-Niedworok Elżbieta, Waniczek Dariusz, Wierzgoń Janusz
Małgorzata Muc-Wierzgoń, Ewa Nowakowska-Zajdel, Sylwia Dzięgielewska-Gęsiak, Teresa Kokot, Katarzyna Klakla, Edyta Fatyga, Department of Internal Diseases, Medical University of Silesia, 41-902 Bytom, Poland.
World J Gastroenterol. 2014 Aug 7;20(29):9759-74. doi: 10.3748/wjg.v20.i29.9759.
Advances in genomics, molecular pathology and metabolism have generated many candidate biomarkers of colorectal cancer with potential clinical value. Epidemiological and biological studies suggest a role for adiposity, dyslipidaemia, hyperinsulinemia, altered glucose homeostasis, and elevated expression of insulin-like growth factor (IGF) axis members in the risk and prognosis of cancer. This review discusses some recent past and current approaches being taken by researches in obesity and metabolic disorders. The authors describe three main systems as the most studied metabolic candidates of carcinogenesis: dyslipidemias, adipokines and insulin/IGF axis. However, each of these components is unsuccessful in defining the diseases risk and progression, while their co-occurrence increases cancer incidence and mortality in both men and women.
基因组学、分子病理学和代谢领域的进展已产生了许多具有潜在临床价值的结直肠癌候选生物标志物。流行病学和生物学研究表明，肥胖、血脂异常、高胰岛素血症、葡萄糖稳态改变以及胰岛素样生长因子（IGF）轴成员表达升高在癌症风险和预后中发挥作用。本综述讨论了肥胖和代谢紊乱研究中一些过去和当前采用的方法。作者将三个主要系统描述为致癌作用中研究最多的代谢候选因素：血脂异常、脂肪因子和胰岛素/IGF轴。然而，这些因素中的每一个都无法确定疾病风险和进展，而它们的共同出现会增加男性和女性的癌症发病率和死亡率。
