Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Cancer Epidemiol Biomarkers Prev. 2010 Jun;19(6):1569-76. doi: 10.1158/1055-9965.EPI-10-0115. Epub 2010 May 25.
UV radiation and pigmentary characteristics may be associated with non-Hodgkin lymphoma (NHL) risk, but few prospective studies exist. We investigated these associations in a Norwegian-Swedish cohort.
The cohort included women ages 30 to 50 years at enrolment in 1991 to 1992. Host factors, and exposure to sun and artificial tanning devices in life-decades 0 to 50 years were collected by questionnaire. Relative risks (RR) with 95% confidence intervals (CI) were estimated by Poisson regression.
Among 104,953 women with complete follow-up through 2006 (Sweden) and 2007 (Norway), 158 were diagnosed with NHL. Women with brown hair had an increased risk of NHL compared with dark brown-haired/black-haired women (RR, 1.72; 95% CI, 1.08-2.74); decreased risks were found among women with gray, green or mixed (RR, 0.50; 95% CI, 0.32-0.77), or blue (RR, 0.54; 95% CI, 0.35-0.81) eyes compared with those with brown eyes, and among those with high propensity to burn compared with those with low propensity (RR, 0.57; 95% CI, 0.36-0.91). Annual number of sunburns and bathing vacations in any age decade, or ever use of artificial tanning devices were not significantly associated with NHL risk. After exposure at ages 10 to 39 years, RRs for ever versus never exposed were 0.99 (95% CI, 0.65-1.50) for sunburn, 1.00 (95% CI, 0.64-1.54) for bathing vacations, and 0.99 (95% CI, 0.67-1.46) for artificial tanning device use.
Whereas several pigmentary characteristics were associated with NHL risk, our results do not support an association between UV radiation and NHL.
Studies of UV radiation and NHL are warranted for etiologic understanding and public health recommendations.
紫外线辐射和色素特征可能与非霍奇金淋巴瘤（NHL）风险相关，但很少有前瞻性研究。我们在挪威-瑞典队列中对此进行了研究。
该队列包括 1991 年至 1992 年入组时年龄在 30 至 50 岁的女性。通过问卷收集宿主因素以及生命十年（0 至 50 岁）内暴露于阳光和人工晒黑设备的情况。通过泊松回归估计相对风险（RR）及其 95%置信区间（CI）。
在 104953 名随访完整的女性中（瑞典至 2006 年，挪威至 2007 年），有 158 人被诊断为 NHL。与深棕色/黑色头发的女性相比，棕色头发的女性 NHL 风险增加（RR，1.72；95%CI，1.08-2.74）；与棕色眼睛相比，灰色、绿色或混合（RR，0.50；95%CI，0.32-0.77）或蓝色（RR，0.54；95%CI，0.35-0.81）眼睛的女性以及高易晒伤倾向的女性与低易晒伤倾向的女性相比，NHL 风险降低（RR，0.57；95%CI，0.36-0.91）。任何年龄阶段的年晒伤次数和沐浴假期次数，或曾经使用过人工晒黑设备，与 NHL 风险均无显著相关性。10 至 39 岁时暴露后，与从不暴露相比，终生暴露的 RR 为 0.99（95%CI，0.65-1.50）用于晒伤，1.00（95%CI，0.64-1.54）用于沐浴假期，0.99（95%CI，0.67-1.46）用于人工晒黑设备使用。
尽管一些色素特征与 NHL 风险相关，但我们的结果不支持紫外线辐射与 NHL 之间的关联。
为了病因理解和公共卫生建议，有必要对紫外线辐射和 NHL 进行研究。
