Department of Oral Frontier Biology, Graduate School of Dentistry, Osaka University, Suita, Osaka, Japan.
J Pharmacol Sci. 2010;113(2):103-9. doi: 10.1254/jphs.09r23fm. Epub 2010 May 24.
Periodontal diseases, some of the most common infectious diseases seen in humans, are characterized by gingival inflammation, as well as loss of connective tissue and bone from around the roots of the teeth, which leads to eventual tooth exfoliation. In the past decade, the association of periodontal diseases with the development of systemic diseases has received increasing attention. Although a number of studies have presented evidence of close relationships between periodontal and systemic diseases, the majority of findings are limited to epidemiological studies, while the etiological details remain unclear. Nevertheless, a variety of recent hypothesis driven investigations have compiled various results showing that periodontal infection and subsequent direct oral-hematogenous spread of bacteria are implicated in the development of various systemic diseases. Herein, we present current understanding in regard to the relationship between periodontal and systemic diseases, including cardiovascular diseases, preterm delivery of low birth weight, diabetes mellitus, respiratory diseases, and osteoporosis.
牙周病是人类最常见的传染病之一，其特征为牙龈炎症，以及牙齿根部周围的结缔组织和骨骼丧失，最终导致牙齿脱落。在过去十年中，牙周病与全身疾病的发展之间的关联受到了越来越多的关注。尽管有许多研究已经提供了牙周病和系统性疾病之间密切关系的证据，但大多数发现仅限于流行病学研究，而病因细节仍不清楚。然而，各种最近基于假设的研究已经综合了各种结果，表明牙周感染和随后细菌通过口腔-血液直接传播与各种系统性疾病的发展有关。在此，我们介绍了目前对于牙周病和全身性疾病之间关系的理解，包括心血管疾病、早产低体重儿、糖尿病、呼吸道疾病和骨质疏松症。
