印度牛弥菜根中2-羟基-4-甲氧基苯甲酸对链脲佐菌素诱导的糖尿病大鼠的影响。
Effect of 2-Hydroxy-4-Methoxy Benzoic Acid from the Roots of Hemidesmus indicus on Streptozotocin-induced Diabetic Rats.
作者信息
Gayathri M, Kannabiran K
机构信息
Biomolecules and Genetics Division, School of Biosciences and Technology, VIT University, Vellore-632 014, India.
出版信息
Indian J Pharm Sci. 2009 Sep;71(5):581-5. doi: 10.4103/0250-474X.58180.
The aim of the present study was to investigate the effect of 2-hydroxy-4-methoxy benzoic acid isolated from the roots of Hemidesmus indicus on plasma glucose, plasma, erythrocyte and erythrocyte membrane lipid peroxidation and membrane-bound Ca(2+) ATPase activity in streptozotocin-induced diabetic rats. In our study, diabetic rats had increased levels of blood glucose and lipid peroxidation in plasma, erythrocytes and erythrocyte membrane and decreased level of plasma insulin and decreased activity of low affinity Ca(2+) ATPase in erythrocytes. Restoration of plasma insulin and glucose in diabetic rats indicates the effect of HMBA on insulin, glucose and lipid peroxidation. HMBA also restored diabetes-induced alterations in the activity of membrane-bound Ca(2+) ATPase. Based on the results of this study it can be concluded that HMBA mediated normalization of membrane-bound ATPase in erythrocytes is due to improved glycemic control and antioxidant activity.
本研究的目的是调查从印度牛弥菜根部分离出的2-羟基-4-甲氧基苯甲酸对链脲佐菌素诱导的糖尿病大鼠的血糖、血浆、红细胞及红细胞膜脂质过氧化作用和膜结合Ca(2+)ATP酶活性的影响。在我们的研究中，糖尿病大鼠的血糖水平升高，血浆、红细胞及红细胞膜的脂质过氧化作用增强，血浆胰岛素水平降低，红细胞中低亲和力Ca(2+)ATP酶的活性下降。糖尿病大鼠血浆胰岛素和血糖的恢复表明了对羟基苯甲酰苹果酸对胰岛素、葡萄糖和脂质过氧化作用的影响。对羟基苯甲酰苹果酸还恢复了糖尿病引起的膜结合Ca(2+)ATP酶活性的改变。基于本研究结果，可以得出结论，对羟基苯甲酰苹果酸介导的红细胞膜结合ATP酶的正常化是由于血糖控制改善和抗氧化活性。
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