Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, and Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, 730000, PR China.
Chem Commun (Camb). 2012 Jan 21;48(6):889-91. doi: 10.1039/c1cc16079f. Epub 2011 Dec 2.
The catalytic asymmetric phospha-Michael reaction of dialkyl phosphine oxides with β,β-disubstituted α,β-unsaturated carbonyl compounds was achieved. The products bearing tetrasubstituted carbon stereocenters were obtained in high yields with excellent enantioselectivities (up to >99% ee).
实现了二烷基氧化膦与β,β-取代的α,β-不饱和羰基化合物的催化不对称膦-Michael 反应。产物具有四取代碳立体中心，产率高，对映选择性极好（高达>99%ee）。
