Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL, 33431-0991, USA.
Chem Commun (Camb). 2022 May 30;58(44):6441-6444. doi: 10.1039/d2cc02090d.
Additions of bulky H-phosphinates to β,β-disubstituted alkenyl ketones under the action of a phase transfer-catalyst led to a new class of carbon quaternary center-containing phosphinates with unprecedented control of the relative configuration of the adjacent carbon and phosphorous chiral centers with high diastereoselectivity in most cases.
在相转移催化剂的作用下，将大体积 H-膦酸酯添加到β,β-二取代的烯基酮中，得到了一类新型的含有碳季铵中心的膦酸酯，其相邻的碳和磷手性中心的相对构型具有前所未有的控制，在大多数情况下具有高非对映选择性。
