Kaufman K D
Merck Research Laboratories, Rahway, New Jersey, USA.
Dermatol Clin. 1996 Oct;14(4):697-711. doi: 10.1016/s0733-8635(05)70396-x.
Androgens, in combination with a genetic susceptibility, have been demonstrated to be required for the development of androgenetic alopecia. Disturbances in androgen metabolism or target organ sensitivity are thought to underlie the pathophysiology of the condition. Observations of patients with disorders of androgen metabolism or function have determined the basic physiology involved in regulation of hair growth by androgens at selective body sites. More recently, in vitro studies of scalp skin and hair follicles have begun to define specific alterations in androgen metabolism at the local level that may play a key role in pathogenesis. The prominent role of 5-reductase in these studies suggests that inhibitors of this enzyme may provide new therapeutic opportunities for patients with androgenetic alopecia.
雄激素与遗传易感性相结合，已被证明是雄激素性脱发发生所必需的。雄激素代谢或靶器官敏感性的紊乱被认为是该病病理生理学的基础。对雄激素代谢或功能紊乱患者的观察确定了雄激素在选择性身体部位调节毛发生长所涉及的基本生理学。最近，对头皮皮肤和毛囊的体外研究已开始确定局部水平雄激素代谢的特定改变，这些改变可能在发病机制中起关键作用。5-还原酶在这些研究中的突出作用表明，该酶的抑制剂可能为雄激素性脱发患者提供新的治疗机会。
