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1
New models for the evaluation of opioid effects in the guinea-pig ileum.豚鼠回肠中阿片类药物作用评估的新模型。
Br J Pharmacol. 1985 May;85(1):61-4. doi: 10.1111/j.1476-5381.1985.tb08831.x.
2
Opioids modulate periodicity rather than efficacy of peristaltic waves in the guinea pig ileum in vitro.阿片类药物在体外调节豚鼠回肠蠕动波的周期性而非效力。
Life Sci. 1980 Jun 2;26(22):1857-65. doi: 10.1016/0024-3205(80)90614-1.
3
Differential effects of SKF 10,047 (N-allyl-normetazocine) on peristalsis and longitudinal muscle contractions of the isolated guinea-pig ileum.SKF 10,047（N-烯丙基去甲左啡诺）对离体豚鼠回肠蠕动和纵肌收缩的不同作用。
Naunyn Schmiedebergs Arch Pharmacol. 1982 Dec;321(3):218-22. doi: 10.1007/BF00505489.
4
Activity of mu- and delta-selective opioid agonists in the guinea pig ileum preparation: differentiation into peptide and nonpeptide classes with beta-funaltrexamine.μ和δ选择性阿片样激动剂在豚鼠回肠制剂中的活性：用β-芬太尼环唑胺区分为肽类和非肽类
J Pharmacol Exp Ther. 1986 Aug;238(2):625-31.
5
Involvement of mu- and kappa-, but not delta-, opioid receptors in the peristaltic motor depression caused by endogenous and exogenous opioids in the guinea-pig intestine.μ和κ阿片受体而非δ阿片受体参与豚鼠肠道内源性和外源性阿片类物质引起的蠕动性运动抑制。
Br J Pharmacol. 2002 Feb;135(3):741-50. doi: 10.1038/sj.bjp.0704527.
6
Calcitonin increases the inhibitory effect of opioids in guinea-pig ileum.降钙素增强阿片类药物对豚鼠回肠的抑制作用。
Gen Pharmacol. 1991;22(1):73-5. doi: 10.1016/0306-3623(91)90311-s.
7
An apparatus to assay opioid activity in the infused lumen of the intact isolated guinea pig ileum.一种用于测定完整离体豚鼠回肠灌注腔内阿片样物质活性的装置。
J Pharmacol Toxicol Methods. 2001 Jan-Feb;45(1):39-46. doi: 10.1016/s1056-8719(01)00116-2.
8
[Inhibitory and excitatory effects of methionine-enkephalin in the isolated rabbit ileum].[甲硫氨酸脑啡肽对离体兔回肠的抑制和兴奋作用]
C R Seances Soc Biol Fil. 1987;181(2):150-5.
9
Inhibition by met-enkephalin of peristaltic activity in the guinea pig ileum, and its reversal by naloxone.甲硫氨酸脑啡肽对豚鼠回肠蠕动活动的抑制作用及其被纳洛酮逆转的情况。
Eur J Pharmacol. 1977 Feb 7;41(3):341-2. doi: 10.1016/0014-2999(77)90329-6.
10
Dual effect of trimebutine on contractility of the guinea pig ileum via the opioid receptors.曲美布汀通过阿片受体对豚鼠回肠收缩性的双重作用。
Gastroenterology. 1991 Dec;101(6):1579-87. doi: 10.1016/0016-5085(91)90395-2.

引用本文的文献

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Evidence- and consensus-based recommendations for the use of pegvaliase in adults with phenylketonuria.基于证据和共识的培维索酶在成年苯丙酮尿症患者中应用的推荐建议。
Genet Med. 2019 Aug;21(8):1851-1867. doi: 10.1038/s41436-018-0403-z. Epub 2018 Dec 14.
2
Enhancement of guinea-pig intestinal peristalsis by blockade of muscarinic M1-receptors.通过阻断毒蕈碱M1受体增强豚鼠肠道蠕动。
Br J Pharmacol. 1988 Mar;93(3):715-20. doi: 10.1111/j.1476-5381.1988.tb10330.x.

本文引用的文献

1
Opioids modulate intestinal peristalsis at a site of action additional to that modulating acetylcholine release.阿片类药物在调节乙酰胆碱释放的作用位点之外的另一个作用位点调节肠道蠕动。
J Pharmacol Exp Ther. 1982 Oct;223(1):271-4.
2
Radioimmunoassay of dermorphin-like peptides in mammalian and non-mammalian tissues.哺乳动物和非哺乳动物组织中类皮吗啡肽的放射免疫分析。
Peptides. 1981;2 Suppl 2:45-9. doi: 10.1016/0196-9781(81)90009-7.
3
Interaction of enkephalin and caerulein on guinea pig small intestine.脑啡肽与蛙皮素对豚鼠小肠的相互作用。
Am J Physiol. 1983 Jan;244(1):G65-70. doi: 10.1152/ajpgi.1983.244.1.G65.
4
Correlation between acetylcholine release and neuronal activity in the guinea-pig ileum myenteric plexus; effect of morphine.豚鼠回肠肌间神经丛中乙酰胆碱释放与神经元活动的相关性；吗啡的作用
Neuroscience. 1982 Feb;7(2):327-40. doi: 10.1016/0306-4522(82)90270-6.
5
D-Tyr--Ser-Gly--Phe--Leu--Thr, a highly preferential ligand for delta-opiate receptors.D-酪氨酰-丝氨酰-甘氨酰-苯丙氨酰-亮氨酰-苏氨酸，一种对δ阿片受体具有高度选择性的配体。
FEBS Lett. 1980 Sep 8;118(2):245-7. doi: 10.1016/0014-5793(80)80229-8.
6
Characterization of the stimulus-induced release of immunoreactive substance P from the myenteric plexus of the guinea-pig small intestine.豚鼠小肠肌间神经丛中刺激诱导的免疫反应性P物质释放的特征
Brain Res. 1984 Apr 9;297(1):127-36. doi: 10.1016/0006-8993(84)90549-3.
7
Evidence for the involvement of substance P in the atropine-resistant peristalsis of the guinea-pig ileum.P物质参与豚鼠回肠抗阿托品蠕动的证据。
Neurosci Lett. 1982 Sep 20;32(1):69-74. doi: 10.1016/0304-3940(82)90231-2.
8
The brain-gut-skin triangle: new peptides.脑-肠-皮肤三角：新的肽类
Peptides. 1981;2 Suppl 2:7-16. doi: 10.1016/0196-9781(81)90003-6.
9
Indirect evidence for the inhibition of enteric substance P neurones by opiate agonists but not by capsaicin.阿片类激动剂而非辣椒素对肠P物质神经元的抑制作用的间接证据。
Eur J Pharmacol. 1982 Feb 5;77(4):273-9. doi: 10.1016/0014-2999(82)90129-7.
10
Distribution of peptide- and catecholamine-containing neurons in the gastro-intestinal tract of rat and guinea-pig: immunohistochemical studies with antisera to substance P, vasoactive intestinal polypeptide, enkephalins, somatostatin, gastrin/cholecystokinin, neurotensin and dopamine beta-hydroxylase.大鼠和豚鼠胃肠道中含肽和儿茶酚胺神经元的分布：用P物质、血管活性肠肽、脑啡肽、生长抑素、胃泌素/胆囊收缩素、神经降压素和多巴胺β-羟化酶抗血清进行的免疫组织化学研究
Neuroscience. 1980;5(4):689-744. doi: 10.1016/0306-4522(80)90166-9.

豚鼠回肠中阿片类药物作用评估的新模型。

New models for the evaluation of opioid effects in the guinea-pig ileum.

作者信息

Donnerer J, Lembeck F

出版信息

Br J Pharmacol. 1985 May;85(1):61-4. doi: 10.1111/j.1476-5381.1985.tb08831.x.

DOI:10.1111/j.1476-5381.1985.tb08831.x
PMID:2992655
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1916762/
Abstract

The pharmacology of morphine and opioid peptides was studied in the guinea-pig ileum by examining their inhibitory effects on propulsive peristaltic activity and on the cooling-induced longitudinal contraction. In these experiments, dose-response curves were recorded. The rank order of potency in inhibiting peristalsis was found to be: dermorphin greater than FK 33-824 greater than dynorphin-(1-17) greater than dynorphin-(1-13) greater than delta-receptor-peptide greater than morphine greater than [Leu] enkephalin, whereas the rank order in inhibiting cooling-induced contractions was found to be: dynorphin-(1-13) congruent to FK 33-824 congruent to dermorphin greater than delta-receptor peptide greater than morphine. Naloxone antagonized the maximally effective dose of each of the opioid agents. In view of the differences between the abilities of these opioids to inhibit propulsive peristaltic activity, these models seem to be valuable for the examination of inhibitory opioid effects in the gut.

摘要

通过检测吗啡和阿片肽对豚鼠回肠推进性蠕动活动及冷诱导纵向收缩的抑制作用，对它们的药理学特性进行了研究。在这些实验中，记录了剂量-反应曲线。结果发现，抑制蠕动的效力顺序为：皮啡肽＞FK 33-824＞强啡肽-(1-17)＞强啡肽-(1-13)＞δ-受体肽＞吗啡＞亮氨酸脑啡肽，而抑制冷诱导收缩的效力顺序为：强啡肽-(1-13)≈FK 33-824≈皮啡肽＞δ-受体肽＞吗啡。纳洛酮可拮抗每种阿片类药物的最大有效剂量。鉴于这些阿片类药物抑制推进性蠕动活动的能力存在差异，这些模型似乎对于研究肠道中阿片类药物的抑制作用具有重要价值。