Department of Obstetrics and Gynecology, Länsi-Pohja Central Hospital, Kemi, Finland.
Arch Gynecol Obstet. 2011 May;283(5):1081-5. doi: 10.1007/s00404-010-1518-x. Epub 2010 May 26.
The aim of this study was to determine whether benign joint hypermobility (BJH) is associated with urogenital prolapse and altered collagen metabolism.
43 postmenopausal women with previous vaginal hysterectomy operated due to genitourinary prolapse were recruited. Each patient was also evaluated for joint hypermobility. The collagen metabolism was studied measuring serum concentrations of type I and III procollagen aminoterminal propeptides and trivalently cross-linked carboxyterminal telopeptide of type I collagen.
Clinical joint hypermobility was found in 35% patients. Women with joint hypermobility had higher concentration of aminoterminal propeptide for type I procollagen and the values were statistically significant (P < 0.0178). Recurrent prolapse was found in 47% of the patients with BJH as compared to non-hypermobile group (25%). In this subgroup the results were statistically significant (P < 0.0085) for type III collagen. Also, the mean serum concentration for type III procollagen was significantly increased above the reference limit.
Women with joint hypermobility have more recurrent genital prolapse as compared to women with normal joint mobility. Plain hypermobility was associated with higher concentrations for type I procollagen. Patients with recurrent prolapse and joint hypermobility have significantly high concentrations for type III procollagen.
本研究旨在确定良性关节过度活动（BJH）是否与泌尿生殖系统脱垂和胶原代谢改变有关。
招募了 43 名绝经后妇女，她们因泌尿生殖系统脱垂而行阴道子宫切除术。每位患者还接受了关节过度活动评估。通过测量血清 I 型和 III 型前胶原氨基末端肽和 I 型胶原三价交联羧基末端肽的浓度来研究胶原代谢。
35%的患者存在临床关节过度活动。关节过度活动的女性 I 型前胶原氨基末端肽浓度更高，且数值具有统计学意义（P < 0.0178）。BJH 患者中 47%出现复发性脱垂，而非过度活动组为 25%（P < 0.0085）。在这个亚组中，III 型胶原的结果具有统计学意义。此外，III 型前胶原的血清平均浓度明显高于参考范围。
与正常关节活动度的女性相比，关节过度活动的女性更易发生复发性生殖器脱垂。单纯的过度活动与 I 型前胶原浓度升高有关。复发性脱垂和关节过度活动的患者 III 型前胶原浓度显著升高。
