School of Health Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, 16150, Malaysia.
Int J Legal Med. 2010 Sep;124(5):415-26. doi: 10.1007/s00414-010-0469-x. Epub 2010 May 26.
The uniparentally inherited mitochondrial DNA (mtDNA) is in the limelight for the past two decades, in studies relating to demographic history of mankind and in forensic kinship testing. In this study, human mtDNA hypervariable segments 1, 2, and 3 (HV1, HV2, and HV3) were analyzed in 248 unrelated Malay individuals in Peninsular Malaysia. Combined analyses of HV1, HV2, and HV3 revealed a total of 180 mtDNA haplotypes with 149 unique haplotypes and 31 haplotypes occurring in more than one individual. The genetic diversity was estimated to be 99.47%, and the probability of any two individuals sharing the same mtDNA haplotype was 0.93%. The most frequent mtDNA haplotype (73, 146, 150, 195, 263, 315.1C, 16140, 16182C, 16183C, 16189, 16217, 16274, and 16335) was shared by 11 (4.44%) individuals. The nucleotide diversity and mean of pair-wise differences were found to be 0.036063 ± 0.020101 and 12.544022 ± 6.230486, respectively.
在过去的二十年中，单亲遗传的线粒体 DNA（mtDNA）成为研究焦点，涉及人类的人口历史和法医亲属关系测试。在这项研究中，分析了来自马来西亚半岛的 248 名无关马来个体的线粒体 DNA 高变区 1、2 和 3（HV1、HV2 和 HV3）。HV1、HV2 和 HV3 的联合分析共揭示了 180 种 mtDNA 单倍型，其中 149 种为独特单倍型，31 种单倍型出现在不止一个个体中。遗传多样性估计为 99.47%，任意两个人共享相同 mtDNA 单倍型的概率为 0.93%。最常见的 mtDNA 单倍型（73、146、150、195、263、315.1C、16140、16182C、16183C、16189、16217、16274 和 16335）由 11 个人（4.44%）共享。核苷酸多样性和成对差异平均值分别为 0.036063±0.020101 和 12.544022±6.230486。
