L-脯氨酸催化的4-氮杂鬼臼毒素衍生物的区域选择性合成及其体外抗癌活性
Regioselective synthesis and in vitro anticancer activity of 4-aza-podophyllotoxin derivatives catalyzed by L-proline.
作者信息
Shi Chunling, Wang Juxian, Chen Hui, Shi Daqing
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, PR China.
出版信息
J Comb Chem. 2010 Jul 12;12(4):430-4. doi: 10.1021/cc100003c.
A series of 4-aza-podophyllotoxin derivatives have been synthesized regioselectively via the three-component reaction of aldehydes, aromatic amines, and tetronic acid catalyzed by l-proline. This method has the advantages of high yield, high regioselectivity, extensive adaptability, easy operation, and environmental friendliness. These compounds were also investigated in vitro, and some were found to have good anticancer activity.
通过L-脯氨酸催化的醛、芳香胺和特窗酸的三组分反应区域选择性地合成了一系列4-氮杂鬼臼毒素衍生物。该方法具有产率高、区域选择性高、适应性广、操作简便和环境友好等优点。还对这些化合物进行了体外研究，发现其中一些具有良好的抗癌活性。
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