Interaction between ceruloplasmin and Sendai virus envelope components. Note VI. Effect of ceruloplasmin on the antigenicity of Sendai virus and subviral fractions.

The results obtained by immunization of rabbits with different Sendai virus antigens (whole virus, envelope fragments and partially purified nucleoprotein) previously incubated with homologous ceruloplasmin confirm the hypothesis of a common protein support for both hemagglutinin and neuraminidase activities, demonstrate the participation of ceruloplasmin in the immune mechanism and reveal the role of the carbohydrate moiety of the glycoprotein in immune response. The probable mechanism of interaction between ceruloplasmin and Sendai virus envelope glycoprotein is discussed.